Distributive and phagocytic characteristics of hepatic macrophages in five cetaceans belonging to Delphinidae and Ziphiidae

The Journal of Veterinary Medical Science
M KawashimaJyoji Yamate

Abstract

Details of morphology and distribution of hepatic macrophages in cetaceans were investigated using the immunohistochemistry with an antibody (SRA-E5) generated against human macrophage scavenger receptor antigen. Liver samples were obtained from five species of cetaceans (Baird's beaked whales, short-finned pilot whales, Risso's dolphins, bottlenose dolphins, and pantropical spotted dolphins). Except for two species of whales, the number of SRA-E5-positive Kupffer cells was greatest in the perivenous zone (zone 3), followed by the mid-zonal (zone 2) and periportal (zone 1) zones; this distribution pattern was different from that in cattle examined here and previously reported rodents with the highest number in zone 1. The frequency of Kupffer cell in each of zones was significantly different among species, and interestingly, the total mean of the Kupffer cell number in three zones increased as the body-length of species was small. In cetaceans, Kupffer cells in zone 1 appeared larger and more stellate in shape, whereas those in zone 3 were smaller and rounder. All cetaceans but Baird's beaked whales had the black pigment-containing Kupffer cells, with the greatest number in zone 3, and macrophages with the similar pigments were...Continue Reading

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Citations

Aug 25, 2009·Veterinary Immunology and Immunopathology·Andreas BeinekeWolfgang Baumgärtner
Nov 23, 2015·Environment International·Jean-Pierre W DesforgesRune Dietz
Sep 5, 2019·Frontiers in Immunology·Sylvain De GuiseRandall S Wells
Jul 28, 2020·Frontiers in Veterinary Science·Shotaro Nakagun, Yoshiyasu Kobayashi

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