PMID: 2567838Jul 1, 1989Paper

Disturbance of cerebral function by aluminium in haemodialysis patients without overt aluminium toxicity

Lancet
P AltmannF Marsh

Abstract

The psychomotor function of 27 long-term haemodialysis patients with apparently normal cerebral function, who had only mildly raised serum aluminium (mean 59 [SEM 9] micrograms/l), was measured by means of a computerised version of the symbol digit coding test. Compared with those of control subjects matched for age and the patients' estimated premorbid IQ, the patients' response times were significantly longer (2.51 [0.10] vs 1.88 [0.05] s). Abnormalities were also detected in five other computerised tests of psychomotor function. The mean activity of erythrocyte dihydropteridine reductase (DHPR), which is inhibited by aluminium, rose during 3 months' desferrioxamine treatment in most of the 15 patients so treated. Although there was no relation between baseline psychomotor function and either indices of cumulative aluminium exposure or erythrocyte DHPR activity, changes in DHPR induced by desferrioxamine correlated with changes in psychomotor performance (r = 0.62). The flash-stimulated visual evoked potential (measured in 10 patients) was delayed (133.4 [2.4] ms), although the pattern-stimulated visual evoked potential remained normal (101.8 [3.2] ms). The difference between the visual evoked potentials stimulated by flash a...Continue Reading

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Related Concepts

Aluminum
Alhydrogel
Desferal
Dihydropteridine Reductase
Drug Evaluation
Erythrocytes
Visual Evoked Cortical Potential
Hemodialysis
Long-term Care
NADH, NADPH Oxidoreductases

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