Disturbance of hippocampal H2S generation contributes to CUMS-induced depression-like behavior: involvement in endoplasmic reticulum stress of hippocampus.

Acta Biochimica Et Biophysica Sinica
Huiying TanXiao-Qing Tang

Abstract

The chronic unpredictable mild stress (CUMS) model is a widely used experimental model of depression. Exogenous stress-induced neuronal cell death in the hippocampus is closely associated with the pathogenesis of depression. Excessive and prolonged endoplasmic reticulum (ER) stress triggers cell death. Hydrogen sulfide (H2S), the third endogenous signaling gasotransmitter, plays an important role in brain functions as a neuromodulator and a neuroprotectant. We hypothesized that the disturbance of endogenous H2S generation and ER stress in the hippocampus might be involved in CUMS-induced depression-like behaviors. Thus, the present study focused on whether CUMS disturbs the generation of endogenous H2S and up-regulates ER stress in the hippocampus and whether exogenous H2S prevents CUMS-induced depressive-like behaviors. Results showed that CUMS-treated rats exhibit depression-like behavior and hippocampal ER stress responses including up-regulated levels of glucose-regulated protein 78, CCAAT/enhancer binding protein homologous protein, and cleaved caspase-12 expression, while the endogenous generation of H2S in the hippocampus is suppressed in CUMS-treated rats. Furthermore, exogenous H2S prevents CUMS-induced depression-like...Continue Reading

References

Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y I ShelineM W Vannier
Sep 1, 1996·Journal of Neurochemistry·L D MorrisonS J Kish
Jan 1, 1997·Annual Review of Psychology·R C Kessler
Feb 29, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C BownL T Young
Oct 25, 2001·Proceedings of the National Academy of Sciences of the United States of America·B CzéhE Fuchs
Feb 15, 2002·The New England Journal of Medicine·Sudha SeshadriPhilip A Wolf
May 10, 2002·Hippocampus·Constantine PavlidesBruce S McEwen
Jun 20, 2002·Bipolar Disorders·Angela L LeeRobert M Sapolsky
Oct 24, 2002·Molecular Neurobiology·Hideo Kimura
Nov 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rui Wang
May 20, 2003·The European Journal of Neuroscience·Deborah N AlfarezHarm J Krugers
Jun 19, 2003·JAMA : the Journal of the American Medical Association·Ronald C KesslerUNKNOWN National Comorbidity Survey Replication
Jul 3, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jessica E Malberg, Ronald S Duman
Oct 17, 2003·The Journal of Biological Chemistry·Rammohan V RaoDale E Bredesen
Nov 25, 2003·Oncogene·David G BreckenridgeGordon C Shore
Dec 5, 2003·Trends in Pharmacological Sciences·Philip K MooreShabbir Moochhala
Dec 20, 2003·Cell Death and Differentiation·S Oyadomari, M Mori
Feb 7, 2004·Cell Death and Differentiation·R V RaoD E Bredesen
May 12, 2004·Free Radical Biology & Medicine·Barney E DwyerMark A Smith
Jun 5, 2004·European Psychiatry : the Journal of the Association of European Psychiatrists·R S Duman
Feb 5, 2005·Nature Medicine·Huda Akil
Feb 18, 2005·Journal of Neurochemistry·Nirinjini NaidooAllan I Pack
Oct 4, 2005·The Journal of Clinical Investigation·Chunyan XuJohn C Reed
Nov 4, 2005·Current Drug Targets. CNS and Neurological Disorders·M BianchiC A Heidbreder
Jan 24, 2006·Nature Reviews. Neuroscience·Olivier Berton, Eric J Nestler
Jan 28, 2006·Stroke; a Journal of Cerebral Circulation·Kun QuPeter T-H Wong
Jul 17, 2007·Neurochemistry International·K QuP T-H Wong
Sep 6, 2008·The International Journal of Neuropsychopharmacology·Akiko HayashiTadafumi Kato
Aug 26, 2009·Neurochemistry International·Boon Hian TanJin-Song Bian
Mar 3, 2011·Nature Cell Biology·Ira Tabas, David Ron
Apr 30, 2011·Experimental Physiology·Hideo Kimura
Jul 5, 2011·Journal of Cellular and Molecular Medicine·Karen M DoyleAfshin Samali
Sep 2, 2011·Biological & Pharmaceutical Bulletin·Mitsue IshisakaHideaki Hara
Jan 19, 2012·Nature Reviews. Molecular Cell Biology·Claudio Hetz
May 5, 2012·American Journal of Physiology. Cell Physiology·Li XieJin-Song Bian
Jul 11, 2012·Neuroscience and Biobehavioral Reviews·Matthew N HillJoanne Weinberg

❮ Previous
Next ❯

Citations

Oct 2, 2015·Acta Biochimica Et Biophysica Sinica·Shenglan GaoXiaoqing Tang
Nov 9, 2019·Molecular Medicine Reports·Jiaxin MaoZhongze Lou
Apr 21, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Ya-Nan ZhaoLin Pei
Oct 1, 2020·International Journal of Molecular Sciences·Mikhail V VoroninSergei B Seredenin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.