Disturbance of intracellular calcium homeostasis and CaMKII/CREB signaling is associated with learning and memory impairments induced by chronic aluminum exposure

Neurotoxicity Research
Biao WangYifu Guan

Abstract

Aluminum-induced neuronal injury has been implicated in various neurodegenerative disorders. However, the underlying mechanism involved in this pathogenesis still remains unknown. Our present findings demonstrated that chronic aluminum exposure resulted in spatial learning impairment and significantly increased intracellular calcium level in the hippocampus of rats. Examination of the associated protein molecules essential for induction and maintenance of long-term potentiation revealed that aluminum exposure could increase the expression level of calmodulin (CaM), but the expression levels of CaM-dependent protein kinase II (CaMKII), and phosphorylated cAMP-responsive element binding protein (CREB) were significantly reduced, whereas the total protein levels of CaMKII and CREB did not change in the aluminum-treated hippocampus. Thus, we provide a previously unrecognized mechanism whereby chronic aluminum exposure impairs hippocampal learning and memory, at least in part, through disruption of intracellular calcium homeostasis and CaM/CaMKII/CREB signaling pathway.

References

Jan 1, 1993·Annual Review of Nutrition·J L Greger
Mar 1, 1996·Neurobiology of Aging·S K BriningM C Chang
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·J H PakK P Huang
Jul 27, 2001·Brain Research Bulletin·B SolomonJ Jossiphov
May 8, 2002·Nature Reviews. Neuroscience·J LismanH Cline
May 28, 2002·Molecular and Cellular Biochemistry·Geetu Raheja, Kiran Dip Gill
Jun 7, 2002·Current Opinion in Neurobiology·Charles C Fink, Tobias Meyer
Jul 12, 2002·Behavioural Brain Research·Makoto MizunoToshitaka Nabeshima
Aug 2, 2003·Biochemical and Biophysical Research Communications·Tomonori KawanoFrédéric Lapeyrie
Apr 1, 1965·Journal of Neuropathology and Experimental Neurology·I KLATZOE STREICHER
Feb 1, 2005·Basic & Clinical Pharmacology & Toxicology·Amarpreet Kaur, Kiran Dip Gill
Oct 4, 2005·Journal of Chemical Neuroanatomy·Ken W S AshwellGeorge Paxinos
Jan 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·John F GuzowskiCarol A Barnes
Apr 22, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·C Exley, M M Esiri
Sep 29, 2006·Journal of Alzheimer's Disease : JAD·Daniel P Perl, Sharon Moalem
Nov 23, 2006·Neuromolecular Medicine·Michael S PetrikChristopher A Shaw
Jan 8, 2009·Physiological Reviews·Cristina M Alberini
Aug 29, 2009·The EMBO Journal·Ling ZhongNashaat Z Gerges
Nov 17, 2009·Biochemical Society Transactions·Mascia AmiciSheila Dargan
Dec 16, 2010·Journal of Alzheimer's Disease : JAD·Lucija Tomljenovic
Apr 12, 2011·Reviews in the Neurosciences·Carlos A Saura, Jorge Valero
May 1, 2010·Environmental Toxicology and Pharmacology·Biao WangXin Deng
Nov 15, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xin CuiWei Xing
Feb 3, 2012·Journal of Visualized Experiments : JoVE·Kanwardeep S KalekaNashaat Z Gerges
Feb 16, 2012·Nature Reviews. Neuroscience·John LismanSridhar Raghavachari
Sep 25, 2012·Molecular Brain·Masanori Sakaguchi, Yasunori Hayashi

❮ Previous
Next ❯

Citations

Mar 7, 2014·International Journal of Molecular Sciences·Chidananda Nagamangala KanchiswamyMassimo E Maffei
Nov 19, 2015·Pharmacology, Biochemistry, and Behavior·Shalini JayantBhupesh Sharma
Apr 25, 2015·Journal of Neuroscience Research·Neha Singla, D K Dhawan
Feb 11, 2018·Molecular and Cellular Biochemistry·Jiuhan ZhaoXiuli Shang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.