PMID: 9523856Apr 2, 1998Paper

Disturbances in biotin metabolism in children undergoing long-term anticonvulsant therapy

Journal of Pediatric Gastroenterology and Nutrition
D M MockK A Lombard

Abstract

In subjects undergoing long-term therapy with carbamazepine and/or phenytoin, reduced plasma concentrations of biotin have been reported. However, the diagnostic value of plasma biotin is unclear, in part because of the presence of significant plasma concentrations of biotin metabolites. Pathologic organic aciduria has also been reported with long-term anticonvulsant therapy, suggesting biotin deficiency, but no mechanism leading to deficiency has yet been determined. In the current study, we sought to determine whether biotin catabolism was accelerated in children receiving long-term treatment with certain anticonvulsants and to assess biotin status as judged by urinary excretion of biotin and 3-hydroxyisovaleric acid, an organic acid that is an indicator of deficiency of a biotin-dependent enzyme. Seven children treated with carbamazepine and/or phenytoin and six treated with phenobarbital provided untimed urine samples. Sixteen healthy children receiving no anticonvulsants served as controls. Biotin and biotin metabolites were determined by high-performance liquid chromatography/avidin-binding assay. Urinary excretion of 3-hydroxyisovaleric acid was determined using gas chromatography/mass spectrometry. Bisnorbiotin excretio...Continue Reading

References

Jul 1, 1992·The Journal of Nutrition·N I Mock, D M Mock
Jan 1, 1989·The American Journal of Clinical Nutrition·H M SaidW Nylander
Oct 1, 1988·Biochemical Medicine and Metabolic Biology·P D Spencer, K S Roth
Nov 1, 1982·Annals of Neurology·K H KrauseJ P Bonjour

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Citations

Sep 6, 2011·Analytical and Bioanalytical Chemistry·Thomas D HorvathGunnar Boysen
Jun 11, 2002·Annual Review of Nutrition·Robert J McMahon
Oct 15, 2010·The American Journal of Clinical Nutrition·Shawna L StrattonDonald M Mock
Oct 27, 2004·Expert Opinion on Drug Safety·Noah Scheinfeld
Nov 3, 2010·Clinics in Dermatology·Melinda Jen, Albert C Yan
Nov 26, 2010·Otolaryngologic Clinics of North America·Bethanee J SchlosserGinat W Mirowski
May 18, 2018·Current Opinion in Pediatrics·Ramrada Lekwuttikarn, Joyce M C Teng
Jan 30, 2002·The American Journal of Clinical Nutrition·Donald M MockNell I Mock
Aug 4, 1998·The American Journal of Physiology·J Zempleni, D M Mock
Mar 4, 1999·The Journal of Nutrition·D M Mock
Jan 4, 2022·European Journal of Nutrition·Alexandra JungertUNKNOWN German Nutrition Society (DGE)

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