PMID: 9160202Apr 1, 1997Paper

Disturbances in the propagation of the slow wave during acute local ischaemia in the feline small intestine

European Journal of Gastroenterology & Hepatology
Wim J E P LammersT Y el-Sharkawy

Abstract

The normal aborad propagation of the slow wave in the small intestine is easily distorted by pacing, hypoxia or transection. We studied whether acute local ischaemia would also induce serious conduction disturbances and ectopic pacemaking. After general anaesthesia and a mid-abdominal incision, a multi-electrode array of 240 extracellular electrodes was positioned on the serosal surface of an exteriorized intestinal loop. Simultaneous recordings of all 240 surface electrodes was performed during a control period and for 5-10 min following local acute arterial occlusion. After the experiments activation maps were constructed describing the pattern of propagation of the slow waves. During control periods, the activation maps showed homogeneous aborad conduction of the slow wave. During acute ischaemia, local areas of inexcitability developed rapidly, merging together to form lines of conduction block. This in turn often provoked the appearance of subsidiary ectopic pacemakers. The location of the conduction blocks as well as that of ectopic pacemakers was highly variable and could disappear and reappear at other sites. Within minutes, acute ischaemia disturbed the organized homogeneous aborad propagation of the slow wave leading ...Continue Reading

Citations

Nov 14, 1997·Trends in Pharmacological Sciences·J D HuizingaJ J Rumessen
Jul 18, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·K LiJ Nie
Mar 16, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·W J E P Lammers
Mar 16, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T R AngeliL K Cheng
Jul 1, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G O'GradyA J Pullan
Aug 27, 2014·Acta Physiologica·W J E P Lammers
Oct 16, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M BouchouchaM Dupres
Aug 11, 1998·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·W J LammersO Pozzan
Feb 12, 2010·Physical Biology·A GizziS Filippi
Jan 5, 2006·Canadian Journal of Physiology and Pharmacology·Wim J E P LammersBetty Stephen
Jan 31, 2018·Frontiers in Physiology·Peng DuLeo K Cheng
Sep 14, 1999·The American Journal of Physiology·R J StevensN G Publicover

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