PMID: 3772098Aug 1, 1986Paper

Disturbances of renal and erythrocyte calcium handling in rats of the Milan hypertensive strain

Journal of Hypertension
M CirilloP Strazzullo

Abstract

Urinary calcium (Ca) excretion and erythrocyte membrane Ca binding and transport were investigated in rats of the Milan hypertensive (MHS) and normotensive strains (MNS). Despite slightly reduced ionized Ca levels in the serum, MHS significantly increased urinary Ca excretion under fasting conditions (P less than 0.01). Urinary Ca was positively related to sodium (Na) excretion in both rat strains; moreover the urinary Ca:Na ratio was significantly enhanced in MHS rats (P less than 0.05). These data suggest that in MHS, Ca reabsorption in the renal tubular cell is reduced independently of disturbances in Na handling. Adenosine triphosphate (ATP)-dependent Ca transport, reflecting the Ca, magnesium (Mg)-ATPase activity (Ca pump), was measured in inside-out vesicles obtained from erythrocyte membranes. This variable was significantly reduced in MHS (P less than 0.01), with no change in the Ca pump affinity constant for Ca. Calcium binding to erythrocyte membranes, measured in the presence of free Ca concentrations comparable with those of the intracellular fluid, was found to be significantly reduced (P less than 0.01) in MHS rats because of the lower number of Ca binding sites. These abnormalities of red blood cell (RBC) Ca hand...Continue Reading

Citations

Sep 1, 1988·Cardiovascular Drugs and Therapy·N M Kaplan
Dec 11, 2008·Calcified Tissue International·Peter VestergaardLeif Mosekilde
Jan 1, 1991·General Pharmacology·F GallettiD J Triggle
Jun 3, 1999·Kidney International·L BorghiA Novarini
Jun 1, 1992·International Journal of Cardiology·R Schleiffer
Jan 1, 1989·European Journal of Clinical Pharmacology·A SalvettiM Freda
Jul 27, 1999·Journal of Hypertension·F P CappuccioP Strazzullo
Jan 1, 1988·Acta Medica Scandinavica·G Ronquist, G Frithz
Oct 3, 2001·Physiological Reviews·H E de Wardener
Feb 8, 2020·Journal of the American Society of Nephrology : JASN·Fan FanRichard J Roman

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