PMID: 517179Jan 1, 1979Paper

Disturbances of the coagulatory system in patients with severe cerebral trauma II. Platelet function

Acta neurochirurgica
L M Auer, E Ott

Abstract

Platelet number, spontaneous aggregation, ADP- and adrenaline-induced aggregation, fibrinogen, and factors 2, 5, 7, and 10, were investigated in a series of 40 consecutive patients admitted to the clinic following severe head injury. Data were evaluated daily during the first week after trauma. Platelets were significantly decreased, particularly in non-survivors; there was no pathological spontaneous aggregation, except in a group of 22.5% of cases who had a mean age of 23.5 years. ADP-induced aggregation was negative in 69% of cases, and adrenaline-induced aggregation was absent in only two non-survivors. Fibrinogen was markedly reduced during the first five days, thereafter normalizing or increasing towards the end of the week. The other investigated values remained within their normal range of 70--130%. The results give no evidence of disseminated intravascular coagulation as a generalized and frequent phenomenon in severely head injured patients. There are, however, signs of latent consumption coagulopathy, which support data from the literature that indicate focal microthrombosis in contused brain areas.

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Citations

Sep 1, 1964·Biulleten' eksperimental'noĭ biologii i meditsiny·Ie AKOPOVV M IADROVA
Jan 1, 1987·Acta neurochirurgica·E KumuraA Kohama
Feb 18, 2005·Journal of Neurotrauma·Martin EngströmPeter Reinstrup
Jun 16, 2006·Journal of Neurotrauma·Diego MoralesSherman C Stein
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May 1, 1983·Journal of Neurosurgery·J J van der SandeM L Bouwhuis-Hoogerwerf
Oct 13, 2006·Clinical Neurology and Neurosurgery·Hamid EtemadrezaieBabak Ganjeifar
Aug 16, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·E MeaudreB Palmier
Oct 24, 2002·Neuroimaging Clinics of North America·John M Hardman, Anthony Manoukian
Sep 25, 2014·Frontiers in Cellular Neuroscience·Christiane Albert-WeissenbergerChristoph Kleinschnitz
Oct 2, 2012·Journal of Neurotrauma·Jianning ZhangJing-fei Dong
Feb 7, 2012·Neurosurgery·Mathieu LarocheGeoffrey T Manley
Jan 2, 2008·Acta neurochirurgica·B S HarhangiA I R Maas
Jan 1, 1990·Acta neurochirurgica·V P SinghM Bhargava
Apr 1, 1981·Journal of Gerontological Nursing·J S Kayser-Jones
Jan 1, 1991·Surgical Endoscopy·K H FuchsH Hamelmann
May 18, 2011·Acta Anaesthesiologica Scandinavica·C BrorssonS Naredi
May 4, 2017·Protein & Cell·Zilong ZhaoJianning Zhang
Nov 5, 2020·Journal of Neurotrauma·Christina M RiojasSusan L Evans

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