Disturbed homocysteine metabolism is associated with cancer

Experimental & Molecular Medicine
Tauheed HasanLaishram Rajendrakumar Singh

Abstract

Hyperhomocysteinemia/Homocysteinuria is characterized by an increased level of toxic homocysteine in the plasma. The plasma concentration of homocysteine is 5-15 μmol/L in healthy individuals, while in hyperhomocysteinemic patients, it can be as high as 500 μmol/L. While increased homocysteine levels can cause symptoms such as osteoporosis and eye lens dislocation, high homocysteine levels are most closely associated with cardiovascular complications. Recent advances have shown that increased plasma Hcy is also a fundamental cause of neurodegenerative diseases (including Alzheimer's disease, Parkinson's disease, and dementia), diabetes, Down syndrome, and megaloblastic anemia, among others. In recent years, increased plasma homocysteine has also been shown to be closely related to cancer. In this review, we discuss the relation between elevated plasma Hcy levels and cancer, and we conclude that disturbed homocysteine metabolism is associated with cancer. Future clinical perspectives are also discussed.

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Citations

May 8, 2020·Oxidative Medicine and Cellular Longevity·Antonio Díaz-QuintanaIrene Díaz-Moreno
Jul 1, 2020·Metabolic Syndrome and Related Disorders·Qingrong PanGuang Wang
Oct 22, 2020·Annals of Clinical and Translational Neurology·Xiaoyan FanYuelei Jin
Nov 15, 2020·Birth Defects Research·Upendra YadavVandana Rai
Dec 29, 2020·Frontiers in Pharmacology·Yiyu WangShaofang Lin
Feb 7, 2021·Molecular Nutrition & Food Research·Alexandra K Loedin, Dave Speijer
Apr 8, 2021·Case Reports in Psychiatry·Vera FroesZita Gameiro
Jun 1, 2021·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Kayla KruppaJeannie van der Linde
Jul 3, 2021·International Journal of Molecular Sciences·Miljana NenkovYuan Chen
Aug 6, 2021·Molecular Neurobiology·Yareth Gopar-CuevasAracely Garcia-Garcia

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Methods Mentioned

BETA
xenografts

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