Disturbed spermatogenic signaling in pituitary adenylate cyclase activating polypeptide-deficient mice

Reproduction : the Official Journal of the Society for the Study of Fertility
D ReglodiT Juhasz

Abstract

PACAP is a neuropeptide with diverse functions in various organs, including reproductive system. It is present in the testis in high concentrations, and in addition to the stage-specific expression within the seminiferous tubules, PACAP affects spermatogenesis and the functions of Leydig and Sertoli cells. Mice lacking endogenous PACAP show reduced fertility, but the possibility of abnormalities in spermatogenic signaling has not yet been investigated. Therefore, we performed a detailed morphological analysis of spermatozoa, sperm motility and investigated signaling pathways that play a role during spermatogenesis in knockout mice. No significant alterations were found in testicular morphology or motility of sperm in homozygous and heterozygous PACAP-deficient mice in spite of the moderately increased number of severely damaged sperms. However, we found robust changes in mRNA and/or protein expression of several factors that play an important role in spermatogenesis. Protein kinase A expression was markedly reduced, while downstream phospho-ERK and p38 were elevated in knockout animals. Expression of major transcription factors, such as Sox9 and phospho-Sox9, was decreased, while that of Sox10, as a redundant factor, was increa...Continue Reading

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Citations

Mar 30, 2018·International Journal of Molecular Sciences·Adam RivnyakDora Reglodi
Oct 23, 2018·GeroScience·D ReglodiA Bardosi
Dec 7, 2019·Journal of Molecular Neuroscience : MN·Gergő JózsaTamás Juhász
Aug 15, 2018·Journal of Molecular Neuroscience : MN·Catalina Abad, Yossan-Var Tan
Sep 20, 2019·International Journal of Molecular Sciences·Patricia Peris-FrauAna Josefa Soler
Aug 14, 2020·International Journal of Molecular Sciences·Vince SzegeczkiTamás Juhász
Aug 9, 2020·Frontiers in Endocrinology·Denes TothDora Reglodi

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