Disturbed Yin-Yang balance: stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1

Acta Pharmaceutica Sinica. B
Chang YanRong-Rong He

Abstract

Herpes simplex virus type 1 (HSV-1), a neurotropic herpes virus, is able to establish a lifelong latent infection in the human host. Following primary replication in mucosal epithelial cells, the virus can enter sensory neurons innervating peripheral tissues via nerve termini. The viral genome is then transported to the nucleus where it can be maintained without producing infectious progeny, and thus latency is established in the cell. Yin-Yang balance is an essential concept in traditional Chinese medicine (TCM) theory. Yin represents stable and inhibitory factors, and Yang represents the active and aggressive factors. When the organism is exposed to stress, especially psychological stress caused by emotional stimulation, the Yin-Yang balance is disturbed and the virus can re-engage in productive replication, resulting in recurrent diseases. Therefore, a better understanding of the stress-induced susceptibility to HSV-1 primary infection and reactivation is needed and will provide helpful insights into the effective control and treatment of HSV-1. Here we reviewed the recent advances in the studies of HSV-1 susceptibility, latency and reactivation. We included mechanisms involved in primary infection and the regulation of late...Continue Reading

Citations

Jul 28, 2020·International Journal of Molecular Sciences·Raquel Bello-MoralesJosé Antonio López-Guerrero
May 14, 2020·Neurotoxicity Research·Hao LiXingshun Xu
Jan 7, 2021·Molecular Neurobiology·Roberta Eduarda GrolliZuleide Maria Ignácio
Jan 13, 2021·Chinese Journal of Integrative Medicine·Di Wang, Miao Qu
Nov 25, 2020·The Journal of Animal Ecology·Caroline K GliddenAnna E Jolles
Feb 13, 2021·Postgraduate Medical Journal·Zihan WangZhensheng Cao
May 8, 2021·Antiviral Research·Kelly S Harrison, Clinton Jones
Jun 20, 2021·MMW Fortschritte der Medizin·Stefanie Sammet, Stefan Esser
Jun 25, 2021·Frontiers in Microbiology·Ying WuAnchun Cheng
Aug 5, 2021·Dementia & Neuropsychologia·Emille Magalhães Neves CamposJúlio César Claudino Dos Santos
Nov 4, 2021·Microbiology Spectrum·Deyan ChenZhiwei Wu

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Methods Mentioned

BETA
Flow cytometry
acetylation

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