Disturbing endoderm signaling to anterior neural plate of vertebrates by the teratogen cadmium

Reproductive Toxicology
Estibaliz L FernándezAnne-Lee Gustafson

Abstract

Cadmium accumulation in the mouse gut endoderm occurs until the closure of the vitelline duct (day 9 post-coitus; p.c.), producing anterior neural tube defects (NTD). The anterior part of the primitive endoderm, designated as the primary signaling center for anterior patterning, expresses several transcription factors of importance for head formation. Here, we studied the expression levels of some of these transcription factors (Hesx1, HNF3beta, Cerl, Otx2 and Sox2), and cell death induced after single cadmium administration to dams on days 7, 8 and 9 p.c. Stage specific down-regulation of Hesx1, Cerl, and Sox2, and an up-regulation of HNF3beta were observed. No effect was seen in Otx2 expression levels. Cell death was increased in the neuroepithelium of the cranial neural folds, and in areas where neural crest cells migrate, but not in the gut endoderm. It is proposed that cadmium-induced NTD is due to interference with head-inductive signals from the endoderm to the adjacent layers.

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Citations

Jun 14, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Meng WangZhong-Tang Zhao
Nov 1, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joshua F RobinsonElaine M Faustman
Oct 5, 2010·Toxicology and Applied Pharmacology·Joshua F RobinsonElaine M Faustman
Sep 21, 2005·Environmental Research·Jean D BrenderKatherine Hendricks
Feb 24, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Şule ÖzelYaprak Engin-Ustun
Jan 22, 2005·Birth Defects Research. Part C, Embryo Today : Reviews·Robert M CabreraRichard H Finnell
Jul 21, 2007·Maternal and Child Health Journal·Lucina SuarezKate Hendricks
Aug 7, 2021·Environment International·Gwen TindulaMaitreyi Mazumdar

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