Disulfide-bond A oxidoreductase-like protein protects against ectopic fat deposition and lipid-related kidney damage in diabetic nephropathy

Kidney International
Xianghui ChenLin Sun

Abstract

Ectopic fat deposition (EFD) in the kidney has been shown to play a causal role in diabetic nephropathy; however, the mechanism underlying EFD remains elusive. By transcriptome analysis, we found decreased expression levels of disulfide-bond A oxidoreductase-like protein (DsbA-L) in the kidneys of diabetic mice (induced by high-fat diet plus Streptozotocin) compared with control mice. Increased expression of adipocyte differentiation-related protein and abnormal levels of collagen I, fibronectin, and phosphorylated 5'AMP-activated kinase (p-AMPK), adipose triglyceride lipase (p-ATGL), and HMG-CoA reductase (p-HMGCR) were also observed in diabetic mice. These alterations were accompanied by deposition of lipid droplets in the kidney, and were more pronounced in diabetic DsbA-L knockout mice. In vitro, overexpression of DsbA-L ameliorated high glucose-induced intracellular lipid droplet deposition in a human proximal tubular cell line, and DsbA-L siRNA aggravated lipid droplet deposition and reduced the levels of p-AMPK, p-ATGL, and p-HMGCR. High glucose and palmitic acid treatment enhanced the expression of interleukin-1β and interleukin-18; these enhancements were further increased after treatment with DsbA-L siRNA but alleviat...Continue Reading

References

Sep 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·Minako ImamuraHajime Nawata
Nov 19, 2002·Diabetologia·D H AtchleyG Virella
Apr 22, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Rachel E ThomsonJohn D Hayes
Feb 10, 2006·The New England Journal of Medicine·Israel F Charo, Richard M Ransohoff
Mar 28, 2006·Journal of the American Society of Nephrology : JASN·Roberto TrevisanGiuseppe Lepore
Nov 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Meilian LiuFeng Liu
Feb 20, 2010·Journal of the American Society of Nephrology : JASN·Thijs W Cohen TervaertUNKNOWN Renal Pathology Society
Jan 26, 2011·Annual Review of Pathology·Yashpal S KanwarSheldon Chen
Mar 25, 2011·Drug Metabolism Reviews·Fabrice Morel, Caroline Aninat
Apr 30, 2011·Acta Diabetologica·Hai-Lu ZhaoSi-En Zeng
May 7, 2011·Nature Medicine·Martin G Myers, Charles F Burant
Jun 7, 2011·Cell Metabolism·Maryam AhmadianHei Sook Sul
Aug 10, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Anneke C BlackburnPhilip G Board
Apr 25, 2012·Annual Review of Biochemistry·Tobias C Walther, Robert V Farese
Dec 29, 2013·Journal of Lipid Research·Michal Herman-EdelsteinUzi Gafter
Apr 30, 2014·American Journal of Nephrology·Lanping JiangLimeng Chen
May 6, 2014·The Lancet. Diabetes & Endocrinology·Aiko P J de VriesUNKNOWN ERA-EDTA Working Group Diabesity
Sep 27, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Katherine R TuttleMark E Molitch
Dec 4, 2014·Arquivos brasileiros de endocrinologia e metabologia·Beatriz R BouvetAdriana M Almará
Oct 6, 2016·PloS One·Fang YuanWeizhou Zhang
Nov 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Juli BaiFeng Liu
Dec 5, 2017·Nature Reviews. Nephrology·Qingzhang Zhu, Philipp E Scherer

❮ Previous
Next ❯

Citations

Sep 20, 2020·Nature Communications·Xiaozhou LiDongshan Zhang
Aug 25, 2020·Oxidative Medicine and Cellular Longevity·Shan XiongLin Sun
Oct 31, 2020·International Journal of Molecular Sciences·Florian JuszczakAnne-Emilie Declèves
Oct 20, 2021·Journal of Molecular Cell Biology·Juli Bai, Feng Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asprosin

Asprosin is a fasting-induced hormone produced in the white adipose tissue to stimulate the hepatic release of glucose into the bloodstream. Discover the latest research on this protein hormone here.