Disulfide-Containing Detergents (DCDs) for the Structural Biology of Membrane Proteins

Chemistry : a European Journal
Dongxiang XueHouchao Tao

Abstract

Disulfide-containing detergents (DCDs) are introduced, which contain a disulfide bond in the hydrophobic tail. DCDs form smaller micelles than corresponding detergents with linear hydrocarbon chains, while providing good solubilization and reconstitution of membrane proteins. The use of this new class of detergents in structural biology is illustrated with solution NMR spectra of the human G protein-coupled receptor A2A AR, which is an α-helical protein, and the β-barrel protein OmpX from E. coli.

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Citations

Aug 21, 2021·Biochemical Society Transactions·Giedre RatkeviciuteTimothy J Knowles

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