Disuse Atrophy of the Aortic Valve After Left Ventricular Assist Device Implantation

The Annals of Thoracic Surgery
Tomoki UshijimaRyuji Tominaga

Abstract

A 31-year-old woman underwent implantation of a DuraHeart left ventricular assist device as bridge to transplantation. Aortic insufficiency was not observed before implantation but developed after implantation and became severe approximately 2 years later. Macroscopically, the aortic valve excised during heart transplantation showed no morphologic alteration. Microscopically, the collagen fibers in the fibrosa layer and the elastic fibers in the ventricularis layer of the valve leaflets were reduced in number, with irregular arrangement. These characteristics can be explained by a disuse atrophic change, and may lead to a better understanding of the mechanism underlying the development of aortic insufficiency.

References

Nov 18, 2000·Circulation·S P HoerstrupJ E Mayer
Jun 27, 2013·Interactive Cardiovascular and Thoracic Surgery·Jerson R MartinaAryan Vink
Nov 7, 2013·Current Heart Failure Reports·Jonathan Holtz, Jeffrey Teuteberg
Dec 18, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Hiroki HataJunjiro Kobayashi

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Citations

Jan 16, 2018·Current Opinion in Cardiology·Mitesh Badiwala, Terrence Yau

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