Diterpenoid alkaloids from Aconitum barbatum var. puberulum Ledeb

Phytochemistry
Nurfida AblajanH A Aisa

Abstract

Seven previously undescribed diterpenoid alkaloids, including five C20-diterpenoid alkaloids, barpuberudine, barpubesines A-D, and two C18-diterpenoid alkaloids, barpubenines A-B, along with 11 known diterpenoid alkaloids were isolated from the whole plant of Aconitum barbatum var. puberulum Ledeb. (Ranunculaceae). Barpuberudine is an unprecedented carbon skeleton of C20-diterpenoid alkaloid, while barpubenines A-B are the first example of rearranged types in C18-diterpenoid alkaloids. Their structures were elucidated based on a comprehensive spectroscopic data analysis. The probable pathway of biogenesis of barpuberudine and barpubenines A-B were discussed. Additionally, the antiarrhythmic, cytotoxic and antimicrobial activities of isolates were also evaluated.

References

Mar 27, 2001·Phytotherapy Research : PTR·A UlubelenS W Pelletier
Oct 1, 1983·Planta medica·Y De-Quan, B C Das
Mar 26, 2010·Natural Product Reports·Feng-Peng WangXiao-Yu Liu
Mar 23, 2011·Journal of Agricultural and Food Chemistry·Zhi Long LiuZhi Wei Deng
Jun 15, 2013·Cardiovascular & Hematological Agents in Medicinal Chemistry·A O BryzgalovE E Shults

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Citations

Nov 23, 2021·Natural Product Research·Nurfida AblajanHaji Akber Aisa

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