Dithiolethiones: a privileged pharmacophore for anticancer therapy and chemoprevention

Future Medicinal Chemistry
Mohd Imran AnsariMohd Kamil Hussain

Abstract

Dithiolethiones are five-membered sulfur-containing cyclic scaffolds that exhibit antioxidative, anti-inflammatory, antithrombic and chemotherapeutic activities. Dithiolethiones display the chemopreventive and cytoprotective effects by activating the antioxidant response element and mounting the transcription of cytoprotective phase II enzymatic machinery. In addition, several classes of dithiolethiones efficiently modulate the activities of proteins that play crucial roles in normal and cancer cells, including glutathione S-transferase, cyclooxygenases and master regulator NF-κB. The present paper summarizes synthetic aspects, pharmacological potentials and biological attributes of dithiolethiones and its derivatives. Additionally, this review concludes with a discussion on how the current state-of-the-art technologies may help in defining a structure-activity relationship of dithiolethiones, thereby facilitating the design and synthesis of potent drug candidates.

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Citations

Jun 20, 2019·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Martin DulacJean-Luc Boucher
Oct 14, 2020·Immunopharmacology and Immunotoxicology·Xiao-Sha LiXin Li
Oct 27, 2020·Frontiers in Pharmacology·Xin AnHua Zhu
May 12, 2020·Bioorganic & Medicinal Chemistry Letters·Shaoyong KeDaye Huang
Apr 3, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Madou-Marilyn DaliJean-Luc Boucher
Apr 2, 2021·Steroids·Arfeen Iqbal, Tabassum Siddiqui
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohammed Hamed AlqarniNikolaos E Labrou

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Methods Mentioned

BETA
ubiquitination
acetylation
xenografts
xenograft

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