DITPA restores the repolarizing potassium currents Itof and Iss in cardiac ventricular myocytes of diabetic rats

Life Sciences
Tania FerrerJosé A Sánchez-Chapula

Abstract

Diabetes Mellitus (DM) can produce an increase in the cardiac action potential duration and QT interval that can be associated with sudden death. These cardiac effects are due to a region-specific decrease in repolarizing outward K(+) currents. Some authors have suggested that the proarrhythmic effects of diabetes can be due to diabetes-induced hypothyroidism. Thus, we have examined the effect of the thyroid hormone analog diiodothyropropionic acid (DITPA) on calcium-independent outward potassium currents in ventricular myocytes from diabetic rats. Sustained (I(ss)) and fast transient outward (I(tof)) K(+) currents were recorded using the whole-cell configuration of the patch-clamp technique. Myocytes were enzymatically isolated from the free wall of the right ventricle, and the epicardial and endocardial layers of the left ventricle of healthy, diabetic and DITPA-treated diabetic rats. Circulating thyroid hormones were measured by electrochemiluminescence. DITPA-treatment of diabetic rats restored I(tof) and I(ss) current densities in cardiac myocytes from the three regions studied, but did not alter current densities in myocytes of control rats. T(3) and T(4) levels were reduced by diabetes, and DITPA-treatment increased circ...Continue Reading

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Citations

Feb 24, 2009·Canadian Journal of Physiology and Pharmacology·Mónica GallegoOscar Casis
Aug 31, 2010·Mathematical Biosciences·Massimiliano ZaniboniMaria Groppi
May 17, 2008·Journal of Molecular and Cellular Cardiology·Céline MarionneauJeanne M Nerbonne
Dec 11, 2014·Current Heart Failure Reports·Viswanathan Rajagopalan, A Martin Gerdes
Feb 2, 2021·World Journal of Diabetes·Nihal OzturkSemir Ozdemir

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