Diuretic activity of squamate mistletoe, Viscum angulatum

Pharmaceutical Biology
R B JadhavS J Surana

Abstract

Viscum angulatum Heyne ex DC (Viscaceae) is a leafless hemiparasitic shrub traditionally used in Asian countries for the treatment of hypertension. In the present study, the methanol extract of the whole plant was examined for diuretic activity in rats. The activity was evaluated using parameters such as urine volume after 5, 19, and 24 h and urine sodium, potassium, and chloride concentrations. The extract was further scrutinized for polyphenolic compounds and triterpenoids. The extract demonstrated a significant increase in and dose-dependent effect on urine excretion volume in comparison to the normal group in the tested range of 100-400 mg/kg. The extract demonstrated comparable saluretic and higher natriuretic activity (Na(+)/K(+)) compared to the furosemide treated group. However, the Cl(-)/Na(+) + K(+) ratio, which indicates carbonic anhydrase mediated activity, remained unaffected. HPLC and quantitative analysis of the extract revealed that polyphenolic compounds and the triterpenoid, oleanolic acid, are the major phytochemicals, and are proposed to be responsible for the observed diuretic effect. Oleanolic acid has been reported to possess diuretic activity with significant potassium loss in rats. In contrast to pure o...Continue Reading

References

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Citations

Jan 1, 2010·Pharmacognosy Research·Namita JadhavR B Jadhav
Sep 11, 2012·Journal of Ethnopharmacology·Caroline Calixto KazamaAntonio Laverde
Dec 28, 2010·Journal of Ethnopharmacology·Arquimedes Gasparotto JuniorCândida Aparecida Leite Kassuya
Apr 22, 2020·Drug Development Research·Devina LobineMohamad F Mahomoodally
Mar 17, 2018·BMC Complementary and Alternative Medicine·Alain N'guessan YaoHenri Die-Kakou
Jul 6, 2020·Archives of Pharmacal Research·Anna SzurpnickaArkadiusz Szterk
May 28, 2021·Journal of Ethnopharmacology·Chuan SongBin Yang

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