PMID: 3761074Oct 1, 1986Paper

Diuretic and hormonal responses to head-out water immersion in nephrotic syndrome

The Journal of Pediatrics
W RascherK Schärer

Abstract

The diuretic and natriuretic response to water immersion, which is known to increase effective central blood volume, was studied in eight edematous children with nephrotic syndrome. The rise in central blood volume was indicated by a decrease in hematocrit from preimmersion median of 40.2% to 38.6% during water immersion (P less than 0.05, Friedman test). Similarly, serum protein concentration fell from 36.7 gm/L to 33.5 gm/L (P less than 0.05). Water immersion induced diuresis from a preimmersion median of 0.33 ml/min/1.73 m2 to 1.52 ml/min/1.73 m2 (P less than 0.05). Osmolar clearance rose, as did sodium and potassium excretion. Urine osmolality fell during water immersion (P less than 0.05). Serum sodium concentration and plasma osmolality did not change. Plasma arginine vasopressin values fell from 11.1 pg/ml to 3.0 pg/ml (P less than 0.05), as did renin activity (8.5 ng to 5.2 ng angiotensin l/ml/hr, P less than 0.01), aldosterone (18.0 ng/dl to 10.1 ng/dl), and norepinephrine (344 pg/ml to 213 pg/ml, P less than 0.05). Water immersion produces a potent natriuretic and diuretic response in children with nephrotic syndrome.

References

Oct 1, 1977·Circulation Research·E HackenthalK G Hofbauer
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Jan 1, 1969·Pflügers Archiv : European journal of physiology·C BehnP Eckert
Feb 1, 1982·Kidney International·G G Krishna, G M Danovitch
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Citations

Jan 1, 1989·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·T TulassayK Schärer
Sep 1, 1992·Clinical Physiology·P Norsk
Feb 1, 2002·Congestive Heart Failure·Karl T WeberRobert B Parker
Mar 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J D Smith, J P Hayslett
Jun 1, 1987·Kidney International·T TulassayK Schärer
Sep 18, 2002·Kidney International·Bernardo Rodríguez-IturbeRichard J Johnson
Jan 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H J PyoR W Schrier
Apr 14, 2016·Current Hypertension Reports·Giorgina Barbara PiccoliTullia Todros
Jan 24, 2018·World Journal of Nephrology·Maria-Eleni RoumeliotiAntonios H Tzamaloukas
Apr 8, 1998·The American Journal of Physiology·J P ValentinM H Humphreys
Feb 1, 2000·The American Journal of the Medical Sciences·A Rasool, P M Palevsky
Jul 1, 1993·The American Journal of the Medical Sciences·B F Palmer
Jan 1, 1994·Kidney International·M H Humphreys
Sep 2, 2008·Heart Failure Clinics·Biff F Palmer

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