Abstract
It is expected that the treatment of hypertension in patients with renal disease decreases the risk of cardiovascular events, but the evidence in these patients is lacking. To assess the effect of diuretic-based treatment on cardiovascular events in patients with isolated systolic hypertension and renal dysfunction. A total of 4336 persons aged 60 years and older with systolic blood pressures of 160 mm Hg and higher and diastolic blood pressures of less than 90 mm Hg were randomly assigned to receive either placebo or chlorthalidone (12.5-25.0 mg/d), with the addition of atenolol (25-50 mg/d) or reserpine (0.05-0.10 mg/d) if needed, and observed for 5 years. The risk of first-occurring cardiovascular events, including stroke, transient ischemic attack, myocardial infarction, heart failure, coronary artery bypass surgery, angioplasty, aneurysm, endarterectomy, sudden death, or rapid death, was stratified according to baseline serum creatinine levels (35.4-84.0, 84.1-101.6, 101.7-119.3, and 119.4-212.2 micromol/L [0.4-0.9, 1.0-1.1, 1.2-1.3, and 1.4-2.4 mg/dL]). Systolic blood pressure reduction was not affected by baseline serum creatinine levels. Active treatment did not affect the risk of serum creatinine levels becoming elevat...Continue Reading
Citations
Oct 16, 2003·Current Cardiology Reports·Bernard Waeber
Jul 8, 2003·Current Hypertension Reports·Bernard Waeber
Nov 6, 2004·Current Hypertension Reports·Gary E Sander
Sep 12, 2000·Current Hypertension Reports·D A Sica
Sep 15, 2000·Journal of the American College of Cardiology·P A McCulloughS Borzak
Mar 12, 2003·Journal of the American College of Cardiology·Rosario V FreemanKim A Eagle
Apr 9, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·R VanholderUNKNOWN European Uremic Toxin Work Group
Sep 11, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Biagio Di IorioAntonio Bellasi
Aug 10, 2004·Current Opinion in Nephrology and Hypertension·Julián SeguraLuis M Ruilope
Jul 2, 2002·The American Journal of Geriatric Cardiology·G E Sander
Jul 12, 2012·International Journal of Clinical Practice·R HajhosseinyD J Goldsmith
Aug 19, 2003·Heart·J J SantopintoUNKNOWN GRACE Investigators
Jun 28, 2013·BMC Nephrology·Andreas KuznikLisa Tarasenko
Dec 5, 2009·Clinical and Experimental Nephrology·UNKNOWN Japanese Society of Nephrology
Mar 15, 2006·Kidney International·B R HemmelgarnB F Culleton
Dec 1, 2012·Kidney International Supplements
Apr 28, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Luca De NicolaUNKNOWN investigators of the TArget Blood Pressure LEvels in Chronic Kidney Disease (TABLE in CKD) Study Group
Jul 14, 2005·Fundamental & Clinical Pharmacology·Julian Segura, Luis M Ruilope
Nov 22, 2005·Seminars in Nephrology·Luca De NicolaUNKNOWN Investigators of TArget Blood Pressure LEvels in Chronic Kidney Disease (TABLE in CKD) Study Group
Sep 6, 2005·Primary Care·Michael MaddensAyham Ashkar
Jun 15, 2004·The American Journal of Cardiology·Jun-ichi YamaguchiUNKNOWN HIJC Study Group
Feb 8, 2005·The American Journal of Cardiology·Pedro A LemosVictor Legrand
Jun 15, 2007·Journal of the American College of Cardiology·Keith A A FoxEugene Braunwald
Dec 21, 2016·The Cochrane Database of Systematic Reviews·Sandy D Shamon, Marco I Perez
Aug 18, 2004·Journal of Hypertension·Julian SeguraAlberto Zanchetti
Oct 6, 2010·Hypertension·John M FlackUNKNOWN International Society on Hypertension in Blacks
Jun 15, 2007·Journal of Hypertension·Luis M RuilopeUNKNOWN VALUE Investigators
Aug 26, 2009·Journal of Hypertension·Trevor A MoriGerald F Watts
Jun 2, 2006·Journal of the American Society of Nephrology : JASN·Marcello TonelliAmit X Garg
Mar 6, 2004·Journal of Human Hypertension·G LeonciniR Pontremoli
Apr 30, 2019·Current Medical Research and Opinion·Anna Posadzy-MalaczynskaJustyna Marcinkowska
Aug 23, 2000·Journal of Hypertension·L V FranseW B Applegate
Mar 19, 2003·Seminars in Dialysis·Bruce F Culleton, Brenda R Hemmelgarn
Sep 9, 2016·Nephrology·Siribha ChangsirikulchaiBandit Thinkhamrop
Feb 28, 2021·Kidney International·UNKNOWN Kidney Disease: Improving Global Outcomes (KDIGO) Blood Pressure Work Group
Aug 23, 2002·Journal of the American Society of Nephrology : JASN·Peter W De LeeuwUNKNOWN Systolic Hypertension in Europe (Syst-Eur) Trial Investigators
Jun 29, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Roberto MinutoloGiuseppe Conte