Diuretic effect of the crude extracts of Carissa edulis in rats

Journal of Ethnopharmacology
Teshome NediKelbessa Urga

Abstract

Carissa edulis (forssk) vahl (Apocynaceae) is used traditionally for the treatment of headache, chest complaints, rheumatism, gonorrhoea, syphilis, rabies and as a diuretic. In the present study, the diuretic activity of different extracts of Carissa edulis was investigated. The diuretic activity of the different extracts of Carissa edulis in a dose range of 50-1000 mg/kg was assessed orally in rats using hydrochlorothiazide as a standard drug. The root bark maceration extract showed no effect on the urine output up to a dose of 1000 mg/kg, while the root bark soxhlet extract produced a significant increase (P < 0.05) in urine output at a dose of 1000 mg/kg. The root wood maceration and root wood soxhlet extracts produced a significant increase in urine output at a dose of 50 mg/kg, with a P-value of <0.05. Urinary electrolyte excretion was also affected by the extracts: the root bark soxhlet extract increased urinary excretion of sodium, potassium and chloride ions; root wood maceration extract increased excretion of sodium and potassium, while root wood soxhlet extract increased excretion of potassium ion. These findings support the traditional use of Carissa edulis as a diuretic agent.

References


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Citations

Sep 8, 2010·Journal of Natural Medicines·Syed Mohammed Basheeruddin Asdaq, Mohammed Naseeruddin Inamdar
Apr 10, 2013·Journal of Ethnopharmacology·J Ya'uI M Hussaini
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Apr 12, 2014·BMC Complementary and Alternative Medicine·Wubshet Hailu, Ephrem Engidawork
Oct 27, 2009·Journal of Ethnopharmacology·Teshale MekonnenEphrem Engidawork
Sep 30, 2008·Journal of Ethnopharmacology·J Ya'uI M Hussaini
Sep 7, 2007·Journal of Ethnopharmacology·C I WrightM M G Koning
Sep 5, 2015·Phytotherapy Research : PTR·Walter ChingwaruPetrina T Kapewangolo
Aug 8, 2009·Chemico-biological Interactions·Syed Mohammed Basheeruddin Asdaq, Mohammed Naseeruddin Inamdar
Jul 4, 2012·Journal of Young Pharmacists : JYP·S Parasuraman, R Raveendran
Oct 31, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·David Bridgman-Packer, Saba Kidanemariam
Mar 1, 2017·Natural Products and Bioprospecting·Joseph Sakah Kaunda, Ying-Jun Zhang
Sep 17, 2020·International Journal of Alzheimer's Disease·Fanta Sabine Adeline YadangElisabeth Ngo Bum
Jun 22, 2019·TheScientificWorldJournal·Sabine Adeline Fanta YadangElisabeth Ngo Bum
Jan 14, 2020·Pakistan Journal of Biological Sciences : PJBS·Yahya Saleh Al-Awthan, Omar Salem Bahattab
Nov 13, 2020·Journal of Medicinal Food·Komlan M Dossou-YovoKwashie Eklu-Gadégbéku
Dec 31, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Gebrelibanos Gebremichael WeluMehari Meles Lema
May 15, 2021·Journal of Toxicology·Komlan M Dossou-YovoKwashie Eklu-Gadégbéku

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