Diuretic herb Gomphrena celosioides Mart. (Amaranthaceae) promotes sustained arterial pressure reduction and protection from cardiac remodeling on rats with renovascular hypertension

Journal of Ethnopharmacology
Paulo César de Paula VasconcelosCandida Aparecida Leite Kassuya

Abstract

Gomphrena celosioides Mart., belonging to the Amaranthaceae family, is a weed known as "perpétua," and its ethnopharmacological use is to treat of urinary tract disorders and kidney stones. Urinary tract disorders and kidney stones could include several pathological conditions such hypertension, diuretic and lithiasic problems. In the present work a model of renovascular hypertension was developed in vivo to investigate its usefulness as an antihypertensive drug. Evaluate the effect of acute and 28 day oral administration of G. celosioides extract on systemic arterial pressure and diuresis of renovascular-hypertensive rats, as well as its effect on cardiac remodeling and vascular reactivity. Ethanolic extract of G. celosioides (EEGC) was used. To induce renovascular hypertension, adult male Wistar rats were submitted to Goldblatt 1K1C or 2K1C surgery. The mean arterial pressure (MAP) of 1K1C animals was directly assessed by cannulation of the carotid artery before and after intraduodenal acute administration of 30, 100 or 300 mg/kg of EEGC. For the 4-week assay, 2K1C animals received daily treatments with water (control group), 100 mg/kg EEGC or 15 mg/kg enalapril for 28 days. Diuresis and caudal blood pressure were assessed we...Continue Reading

Citations

Oct 6, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Luis Fernando Benitez MacoriniCândida Aparecida Leite Kassuya
Dec 28, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Mohammed Ajebli, Mohamed Eddouks
Mar 5, 2021·Journal of Cardiovascular Pharmacology·Juliana Calfa VilhenaCristiane Aguiar da Costa

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