Diuretic response to acute hypertension is blunted during angiotensin II clamp

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Patrick K K LeongAlicia A McDonough

Abstract

Acute hypertension inhibits proximal tubule (PT) fluid reabsorption. The resultant increase in end proximal flow rate provides the error signal to mediate tubuloglomerular feedback autoregulation of renal blood flow and glomerular filtration rate and suppresses renal renin secretion. To test whether the suppression of the renin-angiotensin system during acute hypertension affects the magnitude of the inhibition of PT fluid and sodium reabsorption, plasma ANG II levels were clamped by infusion of the angiotensin-converting enzyme (ACE) inhibitor captopril (12 microg/min) and ANG II after pretreatment with the bradykinin B(2) receptor blocker HOE-140 (100 microg/kg bolus). Because ACE also degrades bradykinin, HOE-140 was included to block effect of accumulating vasodilatory bradykinins during captopril infusion. HOE-140 increased the sensitivity of arterial blood pressure to ANG II: after captopril infusion without HOE-140, 20 ng x kg(-1) x min(-1) ANG II had no pressor effect, whereas with HOE-140, 20 ng x kg(-1) x min(-1) ANG II increased blood pressure from 104 +/- 4 to 140 +/- 6 mmHg. ANG II infused at 2 ng x kg(-1) x min(-1) had no pressor effect after captopril and HOE-140 infusion ("ANG II clamp"). When blood pressure was...Continue Reading

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Citations

Jan 16, 2009·American Journal of Physiology. Renal Physiology·Donna H LeeAlicia A McDonough
Sep 4, 2009·American Journal of Physiology. Renal Physiology·Douglas R YingstWilliam H Beierwaltes
Oct 30, 2009·American Journal of Physiology. Renal Physiology·Anne D M Riquier-BrisonAlicia A McDonough
Jan 29, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alicia A McDonough
Nov 1, 2011·Clinical and Experimental Nephrology·Francesco TrepiccioneGiovambattista Capasso
Mar 12, 2013·Antioxidants & Redox Signaling·Magali Araujo, Christopher S Wilcox
Apr 28, 2005·Clinical and Experimental Pharmacology & Physiology·Erdmann SeeligerH Wolfgang Reinhardt
Aug 5, 2017·Journal of the American Society of Nephrology : JASN·Luciana C VeirasAlicia A McDonough
Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst
Apr 5, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P B Persson
Aug 16, 2003·Current Opinion in Nephrology and Hypertension·Alicia A McDonough, Daniel Biemesderfer
Nov 20, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·William T NoonanJohn N Lorenz
May 24, 2003·Annals of the New York Academy of Sciences·Alicia A McDonoughLi E Yang

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