Diuretic use, RAAS blockade and morbidity in elderly patients presenting to the Emergency Department with non-specific complaints

Swiss Medical Weekly
Juliane M RuedingerRoland Bingisser

Abstract

Up to 20% of elderly patients present to the emergency department (ED) with non-specific complaints (NSC), such as "generalised weakness", the majority suffering from serious conditions requiring timely intervention. Little is known about the use and influence of diuretics and renin-angiotensin-aldosterone (RAAS) blockade on morbidity in those patients. The hypothesis was tested that the use of diuretics and RAAS blockade could be associated with an increased incidence of serious conditions in those patients. During a 23-month period, all adult non-trauma patients with an Emergency Severity Index (ESI) of 2 or 3 were prospectively enrolled. Serious conditions were defined as potentially life-threatening conditions or conditions requiring early intervention to prevent further morbidity and mortality. Study population consisted of 633 patients with median age 82 years, median Charlson comorbidity index 2. 59% of all subjects suffered from a serious condition. 299 subjects (47.2%) used diuretics, of which 65.6% suffered from a serious condition. Combination therapy of RAAS blockade and diuretics was found in 158 subjects (24.9%), 70.3% of which suffered from a serious condition. The intake of two or more diuretics, loop diuretics ...Continue Reading

Associated Clinical Trials

Citations

Oct 21, 2014·The Journal of Clinical Hypertension·Mihály TapolyaiTibor Fülöp
Aug 26, 2014·PloS One·Florian F GrossmannChristian H Nickel
Sep 7, 2012·PloS One·Franziska MatzerChristian Fazekas

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