Diuretics, beta-blockers or both as treatment for essential hypertension

British Journal of Clinical Pharmacology
K O Stumpe, O Overlack


1 Patients with borderline (group I) and sustained hypertension (group II) were treated with beta-blocking drugs, diuretics and the combination of both. In the two groups of patients the antihypertensive effectiveness of both short-term intravenous or chronically oral propranolol was directly related to the extent to which the drug produced an absolute reduction in plasma renin activity (PRA). No such a correlation could be obtained with pindolol. In group I following beta-blockade, day-night profiles of PRA were similar to those observed in group II before treatment. Thus, in this latter subgroup, low renin profiles might reflect reduced beta-adrenergic activity. 2 When the chronically beta-blockaded patients were changed to chronic diuretic therapy it became evident that young hypertensive patients of group II showed a more pronounced BP response than the patients of group I. In those patients of group II in whom pressure was not controlled by the diuretic alone, combination with a beta-blocker led to pressure normalization. 3 The beta-blocking drug induced reduction in pressure was greater in the 25-35 yr olds, than in those older than 55. In contrast, the antihypertensive effect of the diuretic was more pronounced in the 55...Continue Reading


Jul 3, 1976·British Medical Journal·C DavidsonS H Taylor
Jun 1, 1976·British Journal of Clinical Pharmacology·J Hamer
Jun 1, 1974·Archives of Internal Medicine·H R DustanE L Bravo


Jan 1, 1983·Pharmacology & Therapeutics·A J Scriven, P J Lewis
Jan 7, 1984·Lancet·M A WeberJ L Lipson
Nov 26, 1986·The American Journal of Cardiology·M J BowlesE B Raftery
Jun 1, 1983·Journal of Clinical and Hospital Pharmacy·S Hutchison, L M Campbell
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Sep 1, 1981·British Journal of Clinical Pharmacology·E B RafteryJ R Whittington

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