Diurnal and sleep/wake patterns of epileptic spasms in different age groups

Epilepsia
Sriram RamgopalSanjeev V Kothare

Abstract

Epileptic spasms are seizures that occur predominantly in children and are characterized by clusters of brief axial movements. Epileptic spasms may occur in the context of a variety of syndromes. Previous research has found that epileptic spasms occur in a sleep/wake and diurnal rhythm. The purpose of this study was to identify these patterns in different age groups. Charts of 2,021 patients with epilepsy undergoing video-electroencephalography (EEG) monitoring over a 10-year period were reviewed for presence of epileptic spasms and analyzed for their occurrence during the day (6 a.m. to 6 p.m.) or night, out of wake or sleep, and in 3-h time-blocks throughout the day. Exact epileptic spasm time, EEG localization, and the presence or absence of magnetic resonance imaging lesion were also recorded. Patients were separated into two age groups: A ages 3 and under, and over age 3. Statistical analysis of seizure occurrence in time bins was carried out using binomial calculations. p-Values <0.05 were taken as significant. Using exact seizure times, a generalized linear mixed model of the Poisson-family with a square root link function was used to calculate mean seizure times. Age, as a binary variable, and time, as a categorical var...Continue Reading

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Citations

Mar 5, 2013·Current Neurology and Neuroscience Reports·Sriram RamgopalTobias Loddenkemper
Sep 1, 2014·Epilepsy & Behavior : E&B·Sriram RamgopalTobias Loddenkemper
May 20, 2015·Epilepsy & Behavior : E&B·Jolien S van CampenKees P J Braun
Nov 28, 2013·Annals of the New York Academy of Sciences·Juliann M Paolicchi
May 4, 2016·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Esra GurkasErhan Bilir
Jun 15, 2015·Seminars in Pediatric Neurology·Sejal V Jain, Sanjeev V Kothare
Jun 10, 2016·Seizure : the Journal of the British Epilepsy Association·Sigride Thome-SouzaTobias Loddenkemper
May 24, 2014·Expert Review of Neurotherapeutics·Athanasios Covanis
Aug 18, 2020·Seizure : the Journal of the British Epilepsy Association·Bing-Wei PengWen-Xiong Chen

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