Diurnal difference in CAR mRNA expression

Nuclear Receptor
Yuichiro KannoYoshio Inouye

Abstract

BACKGROUND: The constitutive androstane receptor (CAR, NR1I3) plays a key role in the transcriptional activation of genes that encode xenobiotic/steroid and drug metabolizing enzymes. RESULTS: The expression of CAR mRNA throughout the circadian rhythm is reported for the first time in phase with the clock gene Bmal1 and in antiphase with the clock-controlled gene Rev-erbalpha mRNAs, with a peak at Zeitgeber time (ZT) 20 and a trough at ZT8, and a peak/trough ratio of 2.0. The diurnal difference in CAR mRNA expression might underlie the 1.7-fold difference in the magnitude of the PB-dependent induction of CYP2B1/2 mRNA. CONCLUSION: The circadian oscillation of xenosensor gene CAR mRNA expression is partially responsible for chronopharmacokinetics and chronopharmacology in disease.

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Citations

Mar 7, 2012·Chronobiology International·Gianluigi MazzoccoliManlio Vinciguerra
Oct 7, 2016·The Journal of Antimicrobial Chemotherapy·Andrzej BienczakPaolo Denti
Nov 23, 2006·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·F L LimJ G Moggs
Oct 19, 2017·International Journal of Molecular Sciences·Narin OzturkAlper Okyar
Feb 3, 2016·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yoshio Inouye
Mar 5, 2016·PloS One·Céline FeilletMichèle Teboul
Jul 5, 2017·Biochemical Society Transactions·Minnie Fu, Xiaoyong Yang
Oct 8, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Yu-Kun Jennifer ZhangCurtis D Klaassen
Apr 17, 2014·EMBO Reports·Xuan ZhaoRonald M Evans
Aug 14, 2019·British Journal of Pharmacology·Mengjing ZhaoBaojian Wu
Apr 19, 2005·The Journal of Pharmacology and Experimental Therapeutics·Xunshan Ding, Jeff L Staudinger
Aug 14, 2020·The Journal of Biological Chemistry·Masahiko NegishiTatsuya Sueyoshi
Nov 5, 2020·Cells·Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin

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Datasets Mentioned

BETA
AC099236

Methods Mentioned

BETA
PCR
electrophoresis
ChIP
xenosensor

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