PMID: 11924934Apr 2, 2002Paper

Diurnal leptin rhythms in children treated with prednisolone once daily in the morning or in the evening

Journal of Pediatric Endocrinology & Metabolism : JPEM
Ole D Wolthers, Carsten Heuck

Abstract

Serum leptin levels exhibit a marked diurnal variation in children. The aim of the present study was to investigate whether the timing of administration of exogenous glucocorticoids, which have been found to increase serum leptin, affects the diurnal rhythm. Four girls and four boys aged 10.6 to 15.8 (mean 13.2) years with asthma were studied. The design was an open 2-period cross-over trial with a 1-day run in, two 4-day periods of prednisolone 5 mg in the morning or in the evening, with a 3-week washout in between treatment periods. During run in and on the last day of the prednisolone periods a fasting blood sample was drawn at 08.00 h, and thereafter samples were obtained every 2 h throughout the day until 08.00 h the next morning. Serum leptin was measured by a specific radioimmunoassay. During all periods, leptin levels were low during the day with a nadir at 10.00 h (run-in [mean +/- SEM]: 3.9+/-1.28; morning prednisolone: 5.2+/-1.58; evening prednisolone: 5.7+/-2.02 microg/l). Increases in leptin levels were detected from 20.00 h with zeniths at 24.00 h (run in: 7.2+/-1.86; evening prednisolone: 9.2+/-2.36 microg/l) and 02.00 h (morning prednisolone: 9.4+/-1.78 microg/l) (F = 115.5; p <0.01). As compared to run in, lept...Continue Reading

References

Jul 28, 1995·Science·M A PelleymounterF Collins
Feb 23, 1996·The Journal of Biological Chemistry·D W GongB D Weintraub
Mar 1, 1996·The Journal of Clinical Investigation·M K SinhaJ F Caro
Dec 1, 1996·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J P MiellW F Blum
Dec 1, 1996·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·W KiessW F Blum
Oct 6, 1997·The Journal of Clinical Investigation·D A SchoellerJ F Caro
Jan 24, 1998·Metabolism: Clinical and Experimental·T WolthersJ O Jørgensen
Nov 18, 1998·Archives of General Psychiatry·J W NewcomerS Dagogo-Jack
Jan 23, 1999·European Journal of Endocrinology·A ElimamC Marcus
Sep 25, 1999·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·O D Wolthers, J W Honour
Dec 30, 1999·Journal of Pediatric Endocrinology & Metabolism : JPEM·O D WolthersC Skjaerbaek
Jun 24, 2000·Proceedings of the Society for Experimental Biology and Medicine·C A MastronardiS M McCann
May 12, 1995·Science·G W RougierA B Arcucci

❮ Previous
Next ❯

Citations

Dec 3, 2003·Annals of the New York Academy of Sciences·Dan Apter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.