PMID: 3763960Aug 1, 1986Paper

Diurnal rhythm of the in vivo release of enkephalin from the globus pallidus of the rat

Regulatory Peptides
A Bayon, B Antón

Abstract

The in vivo spontaneous release of enkephalin in the globus pallidus of the rat increases from noon to evening by 100%; during this period the local release of exogenous gamma-aminobutyric acid (GABA) decreases by 60%. These diurnal rhythms are more marked in the K+-stimulated release: enkephalin-induced output increases 6-fold while GABA decreases 10-fold during the afternoon and evening hours. Since pallidal enkephalin and GABA are involved in the control of locomotor activity we suggest that these rhythms may be linked to the circadian changes of activity in the rat.

References

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Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A BayonR Guillemin
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Citations

Jan 15, 1992·Biological Psychiatry·B S McEwenR Spencer
Mar 1, 1988·Pharmacology, Biochemistry, and Behavior·A KurumajiK Takahashi
Jan 1, 1994·Brain Research. Brain Research Reviews·J A Angulo, B S McEwen
Oct 29, 2005·The Journal of Comparative Neurology·Ann E KelleyWayne E Pratt
Aug 26, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew J WillAnn E Kelley
Jan 1, 1987·Chronobiology International·Y Tache

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