Abstract
Previous studies showed that portacaval shunting causes metabolic and behavioral changes in rats. Most metabolic changes reversed within 1-2 wk after restoration of normal circulation. However, the rate of cerebral glucose metabolism (CMRGlc) remained depressed in some areas. The question arose whether complete recovery was possible. Therefore, a long-term behavioral study was undertaken to determine the time course of recovery. Diurnal activity was monitored for 48 h each week over a period of 14 wk: 2 wk before shunting, 6 wk after shunting, and 6 wk after restoration of normal hepatic circulation. Nighttime activity was depressed within 1 wk of shunting and did not change. Normal circulation to the liver was reestablished after 6 wk. The diurnal cycle was normal 3 wk later. Thus, although recovery of the diurnal rhythm is possible, the relatively long period necessary suggests the correction of a significant structural or chemical abnormality. A study of CMRGlc was made using the behavioral study as an index of the time necessary for recovery. CMRGlc returned to normal throughout the brain 6 wk after cessation of shunting except in the hippocampus and amygdala (7-8% decrease).
References
Aug 1, 1978·Pharmacology, Biochemistry, and Behavior·M D TricklebankG Curzon
Jul 1, 1992·Gastroenterology·D L CoyA T Blei
Sep 27, 1991·Brain Research·P C ZeeA T Blei
Jun 1, 1986·Pharmacology, Biochemistry, and Behavior·F BengtssonB Jeppsson
Jan 1, 1988·Journal of the Neurological Sciences·F BengtssonA Nobin
Jan 1, 1973·Journal of the Neurological Sciences·A J ZamoraM H Kyu
Oct 1, 1971·Journal of the Neurological Sciences·J B CavanaghM H Kyu
Jan 1, 1971·Journal of the Neurological Sciences·J B Cavanagh, M H Kyu
Feb 1, 1981·Pharmacology, Biochemistry, and Behavior·M D TricklebankG Curzon
Jun 1, 1984·Pharmacology, Biochemistry, and Behavior·A CampbellJ E Fischer
Sep 1, 1994·Journal of Neuroscience Methods·R A HawkinsM R DeJoseph
Sep 1, 1994·Proceedings of the Society for Experimental Biology and Medicine·D D Mousseau, R F Butterworth
Jan 1, 1993·Advances in Experimental Medicine and Biology·J Rodés
Feb 1, 1994·Synapse·M JeziorskiM E Wolf
Mar 1, 1996·Journal of Applied Physiology·P A HawkinsR A Hawkins