Diurnal rhythms in plasma melatonin concentrations in the fetal sheep and pregnant ewe during late gestation

Endocrinology
I Z ZemdegsR Nowak

Abstract

We have measured plasma melatonin (MT) concentrations in the pregnant ewe and fetal sheep during 24-h periods between 114 and 142 days gestation. There was a clear diurnal rhythm in the plasma MT concentrations in both the ewe and fetus from 114 days gestation. Blood samples were also collected from the pregnant ewe and fetus during the day every 2-3 days from 112 days gestation to term. There was no gestational age trend in maternal or fetal day time plasma MT concentrations during late pregnancy. To establish whether there was transplacental transfer of MT, pregnant ewes were injected with [3H]MT, and total radioactivity (disintegrations per min) was measured in maternal and fetal arterial plasma and in amniotic fluid collected before and for 1 h after the [3H]MT injection. Two minutes after [3H]MT injection, radioactivity was detected in both maternal and fetal sheep plasma. Extraction of fetal plasma with chloroform indicated that [3H]MT accounted for 48.0 +/- 7.2 (SE) % of total radioactivity at 2 min after the injection. In one pregnant ewe infused with unlabeled MT (0.3 microgram/ml saline.min for 20 min) maternal and fetal plasma MT concentrations increased within 6 min after the start of the MT infusion. We conclude th...Continue Reading

Citations

Jan 1, 1995·Journal of Neural Transmission. General Section·M ZitouniP Pévet
Oct 15, 1989·Experientia·P J Morgan, L M Williams
Sep 20, 1996·Early Human Development·K L FletcherR I Stark
Apr 1, 1991·Domestic Animal Endocrinology·M E BellM Keller-Wood
Feb 6, 2013·Progress in Biophysics and Molecular Biology·M J BodenD J Kennaway
Oct 9, 2002·Trends in Endocrinology and Metabolism : TEM·David J Kennaway
Oct 15, 1989·Experientia·T J Bartness, B D Goldman
Oct 15, 1989·Experientia·F J Ebling, D L Foster
Mar 1, 1994·The Proceedings of the Nutrition Society·C L Adam, J J Robinson
Mar 31, 2007·Reproduction, Fertility, and Development·B Díaz López, L Debeljuk
Nov 1, 1989·Baillière's Clinical Endocrinology and Metabolism·I C McMillen, R Nowak
Nov 10, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Raj Kamal Srivastava, Amitabh Krishna
Apr 17, 1999·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·S SchenkerM P Lee
Jun 24, 2015·The Journal of Endocrinology·Jonathan D Johnston, Debra J Skene
Nov 22, 2001·American Journal of Obstetrics and Gynecology·T SuzukiK Okamura
Jan 1, 1989·Journal of Biological Rhythms·R I WoodD L Foster
Jun 28, 2005·Journal of the Society for Gynecologic Investigation·Janna L MorrisonK Wayne Riggs
Apr 25, 2018·The Journal of Physiology·Laura BennetRosemary S C Horne
Jan 16, 2020·PloS One·Agnieszka Czekaj-ZastawnyJarosław Wilczyński
Nov 3, 2005·Reproduction, Fertility, and Development·Janna L MorrisonDan W Rurak
Feb 8, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shawn A Rowe, David J Kennaway
Jul 31, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ellen C JensenAlistair J Gunn
Nov 17, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tamara J VarcoeDavid J Kennaway
Aug 1, 1993·The American Journal of Physiology·C L CoulterI C McMillen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.