PMID: 7940144May 1, 1994Paper

Diurnal variation in pulsatile ocular blood flow in normal and glaucomatous eyes

Survey of Ophthalmology
K G Claridge, S E Smith


Ocular blood flow, in particular to the optic nerve head, is considered important in determining the extent of glaucomatous damage. The 24-hour variation in the pulsatile component of ocular blood flow (POBF) was measured using a pneumotonometer linked to the Langham Ocular Blood Flow System. Intraocular pressure (IOP), ocular pulse amplitude, POBF, systemic blood pressure and heart rate were recorded at three-hourly intervals over a 24-hour period in 10 ocular hypertensives, eight patients with primary open angle glaucoma (POAG) treated with timolol eyedrops (G timolol 0.25%), and eight ocular normotensive control subjects. The POAG subjects were readmitted for a second set of 24-hour measurements after temporarily discontinuing G timolol for two weeks. The POBF showed no significant diurnal variation in any of the patient groups, the POAG values being taken from the "off treatment" period. By contrast, there were overnight falls in IOP, ocular pulse amplitude, blood pressure and heart rate, which reached significance in some groups. This suggests that overall there are compensatory changes in IOP, blood pressure, heart rate, and perhaps ocular vascular resistance, to preserve POBF overnight. Within all groups there was much i...Continue Reading


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