PMID: 7940144May 1, 1994Paper

Diurnal variation in pulsatile ocular blood flow in normal and glaucomatous eyes

Survey of Ophthalmology
K G Claridge, S E Smith

Abstract

Ocular blood flow, in particular to the optic nerve head, is considered important in determining the extent of glaucomatous damage. The 24-hour variation in the pulsatile component of ocular blood flow (POBF) was measured using a pneumotonometer linked to the Langham Ocular Blood Flow System. Intraocular pressure (IOP), ocular pulse amplitude, POBF, systemic blood pressure and heart rate were recorded at three-hourly intervals over a 24-hour period in 10 ocular hypertensives, eight patients with primary open angle glaucoma (POAG) treated with timolol eyedrops (G timolol 0.25%), and eight ocular normotensive control subjects. The POAG subjects were readmitted for a second set of 24-hour measurements after temporarily discontinuing G timolol for two weeks. The POBF showed no significant diurnal variation in any of the patient groups, the POAG values being taken from the "off treatment" period. By contrast, there were overnight falls in IOP, ocular pulse amplitude, blood pressure and heart rate, which reached significance in some groups. This suggests that overall there are compensatory changes in IOP, blood pressure, heart rate, and perhaps ocular vascular resistance, to preserve POBF overnight. Within all groups there was much i...Continue Reading

References

Oct 1, 1978·The British Journal of Ophthalmology·B I Williams, W S Peart
May 1, 1992·The British Journal of Ophthalmology·R DavidY Yassur
Jun 1, 1991·Ophthalmology·A L GrajewskiD R Anderson
Jan 1, 1991·Ophthalmic Research·A YoshidaJ W McMeel
Feb 1, 1991·The British Journal of Ophthalmology·D R Trew, S E Smith
Feb 1, 1991·The British Journal of Ophthalmology·D R Trew, S E Smith
Apr 1, 1990·The British Journal of Ophthalmology·M SchulzerW Lau
Jan 1, 1988·Eye·C R Canning, M Restori
Aug 1, 1981·Australian Journal of Ophthalmology·P Henkind, J B Walsh
Sep 1, 1962·The British Journal of Ophthalmology·J E EisenlohrA E Maumenee

❮ Previous
Next ❯

Citations

Sep 1, 1996·Clinical Cardiology·W C Stewart, W P Castelli
Jan 15, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Chantal VulstekeThierry Zeyen
Jan 17, 2013·Japanese Journal of Ophthalmology·Chihiro Mayama, Makoto Araie
Aug 25, 2004·Survey of Ophthalmology·Doina GherghelSelim Orgül
Oct 25, 2003·Progress in Retinal and Eye Research·Vital P CostaLuis Metzner Serra
Oct 9, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Andrew KC LamChi-Ho To
Feb 24, 2004·The British Journal of Ophthalmology·S L HoskingH Garzozi
Dec 19, 2002·The British Journal of Ophthalmology·S L HoskingA K Gupta
Dec 20, 2007·Journal of Glaucoma·Jennifer S WeizerLeon W Herndon
Jan 15, 2003·Current Eye Research·Andrew J MorganBernard Gilmartin
Dec 15, 2011·European Journal of Ophthalmology·Myron KynigopoulosTorsten Schlote
Oct 20, 2019·Survey of Ophthalmology·Kaweh MansouriRobert N Weinreb

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
John H K LiuR N Weinreb
Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
H J KaiserD Stümpfig
© 2021 Meta ULC. All rights reserved