Diurnal variation in resting levels of corticosterone is not mediated by variation in adrenal responsiveness to adrenocorticotropin but involves splanchnic nerve integrity

Endocrinology
I DijkstraF J Tilders

Abstract

To study possible mechanisms controlling diurnal changes in corticosterone (CORT) levels, we tested the CORT responses to ACTH in the morning (AM) and evening (PM) in male Wistar and Sprague-Dawley rats. Rat ACTH-(1-39) or human ACTH-(1-24) (3.75-15 ng/rat) was given as an iv bolus or an intraarterial infusion to (un)anesthetized rats treated with dexamethasone (0.1-0.5 mg/kg, 2-6 h before ACTH). In all conditions studied, no AM/PM differences in CORT responses were found when ACTH was given in vehicle (pH 4.3-7). This contrasts with earlier studies in which ACTH was given in a strongly acid vehicle (pH 1-1.9). Administration of ACTH in such acid vehicle confirmed the reported AM/PM differences in CORT responses (P < 0.05). Because alterations in splanchnic nerve activity can modulate ACTH-induced CORT secretion, we studied the effect of splanchnic nerve transection (SPLNX) on the diurnal change in resting CORT levels in unilaterally adrenalectomized rats. SPLNX reduced resting CORT concentrations in the PM (approximately 50%; P < 0.05), but not in the AM. SPLNX did not abolish the acid vehicle-associated AM/PM differences in CORT responses to ACTH. We conclude that 1) diurnal variation in adrenal responsiveness to ACTH per se ...Continue Reading

Citations

Dec 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Gi Hoon SonKyungjin Kim
Jun 20, 2008·Neuroendocrinology·Dawn H LohJames A Waschek
Dec 16, 2004·The Journal of Clinical Endocrinology and Metabolism·M O van AkenF Roelfsema
Apr 9, 2008·Trends in Endocrinology and Metabolism : TEM·Stefan R BornsteinJames P Herman
May 10, 2006·Genes, Brain, and Behavior·H Oster
Jan 6, 2009·Annals of the New York Academy of Sciences·Monika Ehrhart-Bornstein, Stefan R Bornstein
Mar 19, 2014·Frontiers in Neuroendocrinology·Leonidas Panagiotakopoulos, Gretchen N Neigh
Mar 15, 2016·Psychoneuroendocrinology·Steven A LowranceJohn D Johnson
Jul 25, 2012·The European Journal of Neuroscience·Eleanor J WaiteStafford L Lightman
Mar 11, 2011·Annals of the New York Academy of Sciences·Sooyoung ChungKyungjin Kim
Aug 2, 2011·Frontiers in Neuroendocrinology·Gi Hoon SonKyungjin Kim
Feb 16, 2011·Biochimica Et Biophysica Acta·Sooyoung ChungKyungjin Kim
Jun 19, 2004·Stress : the International Journal on the Biology of Stress·A ClowF Hucklebridge
Sep 6, 2000·Journal of Neuroendocrinology·Y M Ulrich-Lai, W C Engeland
Dec 17, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yvonne M Ulrich-LaiWilliam C Engeland
May 7, 1998·Endocrine Reviews·M Ehrhart-BornsteinG P Vinson
Nov 28, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Brendan D HareWilliam A Falls
Jan 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Dominique SageOlivier Bosler
Mar 10, 2001·Biological Research for Nursing·U E Westfall
May 22, 2009·Endocrinology·Charles W Wilkinson
Aug 1, 1997·The American Journal of Physiology·M S Jasper, W C Engeland
Feb 13, 2001·American Journal of Physiology. Endocrinology and Metabolism·D SageO Bosler
Apr 13, 2018·International Journal of Molecular Sciences·Karol JopekMarcin Rucinski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.