Diurnal variation in synaptic ribbon length and visual threshold

Visual Neuroscience
G W BalkemaT H Nguyen

Abstract

Previous work suggests that photoreceptor synaptic ribbon length and absolute dark-adapted threshold may vary during a 24-h diurnal cycle. To test this hypothesis, we examined the length of photoreceptor synaptic ribbons and the dark-adapted threshold in black (+/+) and albino (c2J/c2J) C57BL/6J mice at six times over a 24-h period. Testing began 2 h after light onset (ZT 2:00) and continued at successive 4-h intervals (12 h:12 h light:dark). We determined the length of the synaptic ribbons in frozen sections by labeling them with an antibody specific for synaptic ribbons. Synaptic ribbons vary in length at different points in the diurnal cycle in both types of mice, but the synaptic ribbons in black mice are longer than those in albino mice by an average of 0.33 microm. The synaptic ribbons of black mice also have a larger response to changes in the light cycle. Ribbon length in black mice ranges from 1.66 microm to 1.4 microm, whereas ribbon length in albino mice ranges from 1.32 microm to 1.25 microm. The shortest ribbons are evident 6 h after light onset in both types of mice, whereas the longest ribbons appear within 2 h after light onset. These changes in synaptic ribbon length support the idea that photoreceptor synaptic...Continue Reading

Citations

Apr 4, 2008·Investigative Ophthalmology & Visual Science·Michael L KoGladys Y-P Ko
Jan 24, 2013·Investigative Ophthalmology & Visual Science·Anne M HannekenWallace B Thoreson
Feb 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Minghui ChenWallace B Thoreson
Apr 7, 2004·The European Journal of Neuroscience·Isabella Spiwoks-BeckerLutz Vollrath
Aug 15, 2015·The European Journal of Neuroscience·Malgorzata JasinskaElzbieta Pyza
Oct 14, 2014·Acta Ophthalmologica·Vilhelm F KoefoedBente E Moen
Feb 24, 2015·Frontiers in Neuroendocrinology·Olivier BoslerAnne-Marie François-Bellan
Dec 17, 2008·Progress in Retinal and Eye Research·Shunbin Xu
Jun 24, 2008·Current Eye Research·Edda ThielsMichael B Gorin
Aug 25, 2009·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Frank Schmitz
Jun 19, 2004·Journal of Neurogenetics·Jean Marc Devaud, Alberto Ferrús
Oct 13, 2017·The Journal of Comparative Neurology·Dale D HunterWilliam J Brunken
Oct 3, 2018·The European Journal of Neuroscience·Gladys Y-P Ko
May 18, 2018·Frontiers in Neural Circuits·Wojciech KrzeptowskiElżbieta Pyza
Nov 25, 2020·International Journal of Molecular Sciences·Roos Anouk Voorn, Christian Vogl
Jul 28, 2020·Neuroscience and Biobehavioral Reviews·Matthew J Hartsock, Robert L Spencer
Oct 30, 2020·Frontiers in Neuroscience·Malgorzata JasinskaJan A Litwin
Aug 19, 2004·Journal of Cell Science·Richard T LibbyKaren P Steel
May 8, 2021·Frontiers in Molecular Neuroscience·Luis Colón-CruzMartine Behra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.