Diurnal variation of tissue-type plasminogen activator and its rapid inhibitor (PAI-1)

Circulation
P AngletonG Schmer

Abstract

Previous studies have shown that overall fibrinolytic activity in blood follows a diurnal rhythm with a peak in the morning and a trough in the evening. The purpose of this study was to determine which fibrinolytic factor(s) was responsible for this diurnal rhythm. Resting and postvenous occlusion tissue-type plasminogen activator (t-PA) activity, resting t-PA antigen, and resting plasminogen activator inhibitor 1 (PAI-1) activity were measured in the morning and evening in 33 healthy men (mean age, 31 years) and in 15 patients (mean age, 57 years) with previous myocardial infarction or unstable angina. PAI-1 activity and t-PA antigen were significantly higher (p less than 0.01) in the morning compared with the evening in controls and patients. In contrast, resting t-PA activity was significantly lower in the morning (p less than 0.01) in both groups and was inversely correlated with PAI-1 activity (r = -0.57, p less than 0.0001). Postvenous occlusion t-PA activity and t-PA capacity were not significantly different between morning and evening in either group. Because t-PA antigen levels and PAI-1 activity were highest in the morning, the variation in t-PA activity was probably not due to decreased secretion of t-PA but instead ...Continue Reading

Associated Clinical Trials

Sep 14, 2015·Maria Colavincenzo

References

Apr 15, 1978·Lancet·M W Millar-CraigE B Raftery
Nov 21, 1985·The New England Journal of Medicine·J E MullerT Robertson
Apr 1, 1986·Clinical Cardiology·G MattioliC Andreoli
Jan 1, 1987·Circulation·J E MullerP H Stone
Aug 31, 1985·British Medical Journal·J A ParamoF van de Werf
Sep 30, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·M B Turton, T Deegan
Jan 1, 1984·Seminars in Thrombosis and Hemostasis·C V Prowse, J D Cash
Sep 1, 1984·International Journal of Cardiology·O JohnsonT Nilsson

❮ Previous
Next ❯

Citations

Sep 1, 1996·Cardiovascular Drugs and Therapy·J A Foley, R C Becker
Jan 31, 2012·European Journal of Clinical Pharmacology·Janka ReimerChristoph A Ritter
Jul 27, 2007·Heart and Vessels·Kyoe TanakaKatsusuke Yano
May 10, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Patricia KrüthRalf Zahn
Nov 29, 2007·European Journal of Applied Physiology·Leif-Hendrik BoldtHanns-Christian Gunga
Aug 27, 2013·European Journal of Applied Physiology·Brian R KupchakJeff S Volek
Oct 14, 2008·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Giuseppe Micieli, Anna Cavallini
Jan 30, 2013·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Xu Ma, Qing-Yun Zhang
Jun 30, 1994·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H A BremerH C Wallenburg
Mar 15, 1991·Journal of the American College of Cardiology·D AlexopoulosE A Fisher
Jun 1, 1992·Journal of the American College of Cardiology·W L ChandlerJ C Beard
Jul 1, 1995·Journal of the American College of Cardiology·M A Siddiqui
Jul 1, 1994·Journal of the American College of Cardiology·R A WrightK A Fox
Mar 15, 1996·Journal of the American College of Cardiology·T KonoA Fujiwara
Sep 1, 1996·Critical Reviews in Oncology/hematology·W L Chandler
Mar 23, 2005·Current Opinion in Pharmacology·Bart De TaeyeDouglas E Vaughan
May 27, 2005·Neuroscience Letters·Jian WangQiqiang Liu
May 10, 2003·Journal of Molecular and Cellular Cardiology·John A SchoenhardDouglas E Vaughan
Jun 4, 1998·Thrombosis Research·R ManfrediniC Fersini
Jun 25, 2003·Journal of the American College of Cardiology·Jose P S HenriquesUNKNOWN Zwolle Myocardial Infarction Study Group
May 8, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Norihiko Takeda, Koji Maemura
Mar 27, 2009·Nature Reviews. Nephrology·Hunjoo HaHi B Lee
Dec 11, 2002·British Journal of Haematology·Per Ole IversenPer Morten Sandset
Jun 15, 2000·The New England Journal of Medicine·H P Kohler, P J Grant
Mar 30, 2006·Journal of Cardiopulmonary Rehabilitation·Adam T deJongBarry A Franklin
Sep 20, 2007·Journal of Cardiovascular Pharmacology·Anna R DoverDavid E Newby
Jun 1, 1992·Australian and New Zealand Journal of Medicine·R M NorrisH D White
Feb 1, 1994·Alcoholism, Clinical and Experimental Research·P R Eisenberg
Feb 15, 2005·International Journal of Clinical Practice·M Agirbasli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.