PMID: 6538621Feb 1, 1984

Diurnal variations in estradiol binding site concentrations in the hypothalamus, pituitary and uterus of prepuberal rats

Journal of Steroid Biochemistry
G Barbanel, I Assenmacher


Available cytosolic estradiol binding sites (EBS) were estimated at 6 h intervals over a 24 h period in individual extracts of uteri, pituitaries and hypothalami from intact, ovariectomized or hypophysectomized 28-day old rats, maintained from birth in a 12 h light-12 h dark photoperiod. Plasma estrogen levels were also recorded, in intact rats, they displayed a 20% rise during daytime. In the uterus and pituitary of ovariectomized rats EBS concentrations exceeded by one third those of intact controls. In intact animals, significant diurnal variations in EBS were observed in both these tissues, with increased daytime levels. These variations appeared to depend on the amount of estrogen in the plasma, as they were not observed in spayed rats. No diurnal variations in EBS were apparent in the hypothalamus of intact animals, but they did occur in ovariectomized rats, and even more significantly in hypophysectomized rats, although the latter had lower EBS concentrations than spayed animals. These variations were presumed to result from the interference of pituitary-controlled hormones other than estrogens in the regulation of EBS levels.


Oct 1, 1977·Analytical Biochemistry·V F Kalb, R W Bernlohr
May 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J UrielM Dupiers
Jan 1, 1979·Endocrine Research Communications·M K VaughanP J Sheridan
Mar 1, 1978·Biology of Reproduction·J A Cidlowski, T G Muldoon
Mar 1, 1978·The Journal of Clinical Endocrinology and Metabolism·P A LeeA A Kowarski
Nov 1, 1977·European Journal of Biochemistry·G BarbanelJ C Mani
Oct 1, 1976·Molecular and Cellular Endocrinology·A HughesP W Jungblut
Oct 1, 1976·Acta Endocrinologica·K D Döhler, W Wuttke
Dec 1, 1976·The Journal of Clinical Endocrinology and Metabolism·R M BoyarJ W Finkelstein
Jun 1, 1980·Molecular and Cellular Endocrinology·G Barbanel, I Assenmacher
Jan 1, 1982·Journal of Steroid Biochemistry·P Singh, T G Muldoon
Nov 1, 1982·Molecular and Cellular Endocrinology·G Barbanel, I Assenmacher
Feb 1, 1964·Endocrinology·G FALCONI, G L ROSSI


Aug 1, 1988·Digestive Diseases and Sciences·N H RubinJ C Thompson

Related Concepts

Circadian Rhythms
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