PMID: 6540340Aug 6, 1984Paper

Diurnal variations of S-adenosyl-L-methionine and adenosine content in the rat pineal gland

Life Sciences
B ChabannesH Pacheco

Abstract

S-adenosylmethionine and adenosine levels in the rat pineal gland were determined by high-performance liquid chromatography after fractionation of the pineal extracts. The concentration of S-adenosylmethionine follows a circadian rhythm and is about three times higher during the day (2.5 nmol/gland) than the night (1.1 nmol/gland). The variations in the level of adenosine are apparently more complex. Over the 24 hours period there are two maxima at 03.00 (120 pmol/gland) and 15.00 hrs (100 pmol/gland) and one minimum at 09.00 hrs (50 pmol/gland). In addition, only an ultradian rhythm with a period of 12 hrs and an acrophase of 3 hrs can be evinced by computer analysis.

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Citations

Jan 1, 1986·Neuroscience and Biobehavioral Reviews·P B FoleyA Foldes
May 1, 1985·Biological Psychiatry·J A Goldstein
Jul 20, 2005·Annals of Medicine·Christian A Kell, Jörg H Stehle
Jun 1, 2010·Acta Physiologica Hungarica·C L Sánchez LópezJ Cubero

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