PMID: 16629177Apr 25, 2006Paper

Divalent cations as modulators of neuronal excitability: emphasis on copper and zinc

Biological Research
Ricardo DelgadoD Wolff

Abstract

Based on indirect evidence, a role for synaptically released copper and zinc as modulators of neuronal activity has been proposed. To test this proposal directly, we studied the effect of copper, zinc, and other divalent cations on voltage-dependent currents in dissociated toad olfactory neurons and on their firing rate induced by small depolarizing currents. Divalent cations in the nanomolar range sped up the activation kinetics and increased the amplitude of the inward sodium current. In the micromolar range, they caused a dose dependent inhibition of the inward Na+ and Ca2+ currents (INa and ICa) and reduced de amplitude of the Ca2+-dependent K+ outward current (ICa-K). On the other hand, the firing rate of olfactory neurons increased when exposed to nanomolar concentration of divalent cations and decreased when exposed to micromolar concentrations. This biphasic effect of divalent cations on neuronal excitability may be explained by the interaction of these ions with high and low affinity sites in voltage-gated channels. Our results support the idea that these ions are normal modulators of neuronal excitability.

Citations

Nov 12, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Fernando C OrtizJulio Alcayaga
Oct 16, 2015·The European Journal of Neuroscience·Carlos MaureiraCecilia Vergara
Oct 17, 2017·Frontiers in Cellular Neuroscience·Laura J Blakemore, Paul Q Trombley
Apr 25, 2020·Viruses·Nabab KhanJonathan D Geiger
Oct 24, 2018·Cell Communication and Signaling : CCS·Julianna KardosKatalin Jemnitz
Oct 25, 2020·Bulletin of Experimental Biology and Medicine·E I SolntsevaV G Skrebitsky
Mar 21, 2008·Environmental Science & Technology·Jenifer K McIntyreNathaniel L Scholz

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