Divalproex sodium (Depakote) for alcohol withdrawal and relapse prevention

Journal of Addictive Diseases
Lance P LongoSandra Hubatch

Abstract

This pilot study evaluates the safety and efficacy of divalproex sodium (Depakote) for alcohol withdrawal and relapse prevention. Sixteen patients in moderate alcohol withdrawal were randomized to receive a standard benzodiazepine detoxification, depakote detoxification, or depakote detox plus maintenance. Symptom reduction occurred more rapidly and consistently in the depakote treated patients than in the benzodiazepine control group, and at six-week follow up a greater percentage of patients in the depakote maintenance group were completely abstinent than either detox-only group. There were no significant differences in sociodemographic or drinking data amongst the three cohort samples at baseline. Our findings suggest that the anticonvulsant divalproex sodium (Depakote) may be a safe and efficacious alternative to benzodiazepines for the treatment of alcohol withdrawal. It may be an advantageous alternative for outpatient detoxification, as it has no abuse potential, pharmacologic synergy with alcohol, or substantial cognitive or psychomotor side effects.

References

Dec 1, 1988·The American Journal of Psychiatry·D A CirauloR I Shader
Jan 1, 1995·Journal of Addictive Diseases·G Y MinukL Hoeschen
Jul 22, 1998·The Journal of Clinical Psychiatry·A J SaxonV M Haver
Mar 9, 1999·Alcoholism, Clinical and Experimental Research·M WojnarD Wasilewski
Jan 26, 2000·Journal of Clinical Psychopharmacology·L L DavisF Petty
Feb 9, 2000·The Journal of Clinical Psychiatry·R M HirschfeldJ M Russell
Mar 16, 2000·The American Journal of Drug and Alcohol Abuse·H MyrickR Malcolm
Mar 3, 2005·Psychiatric Annals·H J Bursztajn, A Brodsky

❮ Previous
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Citations

May 6, 2006·Journal of Affective Disorders·Icro MaremmaniHagop S Akiskal
Mar 15, 2005·Psychopharmacology·George R BreeseDarin J Knapp
Sep 10, 2004·Current Psychiatry Reports·Hugh Myrick, Raymond Anton
Nov 8, 2012·Advances in Therapy·Riccardo GuglielmoLuigi Janiri
Nov 18, 2006·Expert Opinion on Pharmacotherapy·Michael Soyka, Susanne Roesner
Oct 6, 2004·Expert Opinion on Pharmacotherapy·Darlene H Moak
Jun 7, 2005·Expert Opinion on Emerging Drugs·Raye Z LittenMark Egli
Aug 30, 2008·Substance Use & Misuse·David RossG Michael Allan
Feb 15, 2008·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Michael SoykaUNKNOWN WFSBP Task Force on Treatment Guidelines for Substance Use Disorders
Sep 25, 2012·Critical Care Clinics·Richard W CarlsonShivaramaiah Shashikumar
Oct 20, 2007·European Psychiatry : the Journal of the Association of European Psychiatrists·Nadir A Aliyev, Zafar N Aliyev
Nov 22, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Lorenzo LeggioRobert M Swift
May 8, 2007·Pharmacology, Biochemistry, and Behavior·Clifford M KnappConan Kornetsky
Jun 15, 2005·Bipolar Disorders·Lakshmi N YathamUNKNOWN Canadian Network for Mood and Anxiety Treatments
Jul 15, 2004·Alcoholism, Clinical and Experimental Research·C L KliethermesJ C Crabbe
Apr 29, 2004·Alcoholism, Clinical and Experimental Research·Bankole A JohnsonRobert J Malcolm
Dec 13, 2006·Bipolar Disorders·Mark A Frye, Ihsan M Salloum
Feb 28, 2006·Alcoholism, Clinical and Experimental Research·Bankole A JohnsonNassima Ait-Daoud
Apr 23, 2015·CNS Drugs·Riccardo GuglielmoLuigi Janiri
May 2, 2003·Psychopharmacology·David H Epstein, Kenzie L Preston
Nov 20, 2004·The Psychiatric Clinics of North America·Hugh MyrickHamilton Peters
May 23, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Zafar N Aliyev, Nadir A Aliyev
Feb 23, 2011·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Florian EyerThomas Zilker
Dec 23, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Michael SoykaUNKNOWN WFSBP Task Force on Treatment Guidelines for Substance Use Disorders
Mar 4, 2017·Neuropharmacology·Anna S Warden, R Dayne Mayfield
Mar 2, 2006·The Annals of Pharmacotherapy·Elaine LumRichard S Slavik
Jul 1, 2017·Expert Opinion on Pharmacotherapy·Michael Soyka, Christian A Müller
Jan 9, 2014·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Barbora MainerovaRomana Bradacova
Mar 7, 2007·CNS Drugs·George A KennaRobert M Swift
Feb 20, 2010·Behavioural Pharmacology·Pravinkumar Satyanarayan BhutadaDharmendra R Mundhada
Nov 26, 2010·Journal of Clinical Psychopharmacology·Christoph RichterMartin Schaefer
Jan 18, 2006·Journal of Clinical Psychopharmacology·Joseph P ReouxDanny Shen
Sep 29, 2005·The American Journal on Addictions·John J Mariani, Prameet Singh
May 24, 2019·The Journal of Neuropsychiatry and Clinical Neurosciences·Ricardo E JorgeStephan Arndt
Mar 20, 2010·The Cochrane Database of Systematic Reviews·Silvia MinozziMarina Davoli
Mar 20, 2010·The Cochrane Database of Systematic Reviews·Laura AmatoMarina Davoli
Jul 31, 2019·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Maria PainoPaul M Roman
Mar 21, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Dahea YouLauren M Aleksunes
Mar 22, 2019·Journal of Biochemical and Molecular Toxicology·Dahea YouLauren M Aleksunes
Oct 4, 2020·Pharmacoepidemiology and Drug Safety·Lidia M V R MouraJohn Hsu
Jun 28, 2008·The American Journal of Drug and Alcohol Abuse·Ofra Sarid-SegalDomenic Ciraulo
Feb 25, 2005·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Marcos ZaleskiTadeu Lemos

❮ Previous
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