PMID: 11313091Apr 21, 2001Paper

Divalproex sodium in sex offenders with bipolar disorders and comorbid paraphilias: an open retrospective study

Journal of Affective Disorders
E NelsonS L McElroy

Abstract

This study evaluated divalproex response in sex offenders with a bipolar disorder. We reviewed the records of all sex offenders who participated in a residential rehabilitative program who received divalproex for treatment of a bipolar disorder. Patients' mood symptoms and, when present, comorbid paraphilic symptoms, were retrospectively assessed using the CGI severity scale. Sex offenders displayed significant improvement in manic symptoms with divalproex treatment. However, there was no significant improvement in paraphilic symptoms in the subset of patients admitting to these symptoms. Divalproex may be effective for manic symptoms in sex offenders with a bipolar disorder. However, for bipolar sex offenders with comorbid paraphilias, the drug may not be effective for paraphilic symptoms. This study was limited by its retrospective, open-label design, lack of systematic means of assessing manic and paraphilic symptoms, and small sample size. Divalproex may be a helpful adjunct in the treatment of the subset of sex offenders who have a bipolar disorder.

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Citations

May 1, 2001·Yeast·C CompagnoD Porro
Apr 10, 2010·Archives of Sexual Behavior·Giorgio Corretti, Irene Baldi
Apr 5, 2012·Law and Human Behavior·Robert D MorganJarrod S Steffan
Mar 24, 2004·Paediatric Drugs·Priscille Gerardin, Florence Thibaut
Feb 23, 2020·Neurocase·Pedro Maranhão Gomes LopesRicardo de Oliveira-Souza
May 13, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Florence ThibautUNKNOWN WFSBP Task Force on Sexual Disorders
May 27, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Florence ThibautUNKNOWN WFSBP Task Force on Paraphilias

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