Divergence of fMRI and neural signals in V1 during perceptual suppression in the awake monkey.

Nature Neuroscience
Alexander MaierDavid A Leopold

Abstract

The role of primary visual cortex (V1) in determining the contents of perception is controversial. Human functional magnetic resonance imaging (fMRI) studies of perceptual suppression have revealed a robust drop in V1 activity when a stimulus is subjectively invisible. In contrast, monkey single-unit recordings have failed to demonstrate such perception-locked changes in V1. To investigate the basis of this discrepancy, we measured both the blood oxygen level-dependent (BOLD) response and several electrophysiological signals in two behaving monkeys. We found that all signals were in good agreement during conventional stimulus presentation, showing strong visual modulation to presentation and removal of a stimulus. During perceptual suppression, however, only the BOLD response and the low-frequency local field potential (LFP) power showed decreases, whereas the spiking and high-frequency LFP power were unaffected. These results demonstrate that the coupling between the BOLD and electrophysiological signals in V1 is context dependent, with a marked dissociation occurring during perceptual suppression.

References

Aug 18, 1989·Science·N K Logothetis, J D Schall
Jun 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R Gruetter
Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·M I Posner, C D Gilbert
May 2, 2000·Vision Research·V A LammeH Spekreijse
Jul 19, 2001·Nature·Y S BonnehD Sagi
Feb 2, 2002·Nature Reviews. Neuroscience·Randolph Blake, Nikos K Logothetis
Sep 10, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Nikos K Logothetis
Mar 4, 2003·Nature Reviews. Neuroscience·Frank Tong
Apr 8, 2003·Journal of Vision·Sang-Hun Lee, Randolph Blake
Sep 16, 2003·Neuron·Melanie WilkeDavid A Leopold
Apr 22, 2004·Nature Reviews. Neuroscience·Costantino Iadecola
Dec 8, 2004·Nature Neuroscience·Sang-Hun LeeDavid J Heeger
Jul 30, 2005·Current Biology : CB·John-Dylan Haynes, Geraint Rees
Aug 6, 2005·Science·Jörn NiessingRalf A W Galuske
Oct 20, 2005·Nature Neuroscience·Klaus WunderlichSabine Kastner
Sep 26, 2006·Trends in Cognitive Sciences·Frank TongRandolph Blake
Nov 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Melanie WilkeDavid A Leopold
Mar 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Alexander MaierDavid A Leopold
Sep 11, 2007·Nature Neuroscience·Ahalya Viswanathan, Ralph D Freeman
Mar 20, 2008·International Journal of Biomedical Imaging·Claudine Gauthier, Richard D Hoge

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Citations

Nov 28, 2013·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Phillip C F LawTrung T Ngo
Jan 23, 2009·Nature·David A Leopold
Jun 11, 2010·Nature·David A Leopold
Oct 25, 2011·Nature Neuroscience·Dobromir RahnevHakwan Lau
Jul 31, 2012·Nature Neuroscience·Mariana M B CardosoAniruddha Das
Jun 19, 2013·Nature Neuroscience·Eran EldarYael Niv
Dec 19, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael X CohenThomas E Schlaepfer
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Galit PelledAlan P Koretsky
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Marieke L SchölvinckDavid A Leopold
Apr 29, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jeroen J A van BoxtelChristof Koch
Aug 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Megan WangBiyu J He
Feb 12, 2010·Social Cognitive and Affective Neuroscience·M Justin KimPaul J Whalen
Jun 22, 2012·Annual Review of Neuroscience·David A Leopold
May 6, 2009·Journal of Cognitive Neuroscience·Marieke L Schölvinck, Geraint Rees
Jul 8, 2009·Journal of Cognitive Neuroscience·Edit FrankóRufin Vogels
Nov 26, 2009·Journal of Cognitive Neuroscience·Jan W BrascampRandolph Blake
Jun 23, 2012·Journal of Cognitive Neuroscience·Yasuki NoguchiRyusuke Kakigi
Mar 16, 2013·Journal of Cognitive Neuroscience·Jeffrey S TaubeRyan M Yoder
Sep 3, 2010·The Journal of Clinical Investigation·Julie Blumberg, Gabriel Kreiman
Jun 24, 2011·PLoS Computational Biology·Maria J RosaWill D Penny
Apr 24, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Clinton B McCracken, Anthony A Grace
Jun 24, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiaoxuan JiaAdam Kohn
Sep 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Georgios A KelirisAndreas S Tolias
Jun 25, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Melanie WilkeDavid A Leopold
Nov 16, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Preeti VergheseAlex R Wade
Mar 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Biyu J He
Feb 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tobias H DonnerDavid J Heeger
Jun 7, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shlomit Yuval-Greenberg, David J Heeger
Feb 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander MaierDavid A Leopold
Jul 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Han YuanBin He
Mar 19, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Theofanis I PanagiotaropoulosNikos K Logothetis
May 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Melanie WilkeDavid A Leopold
Apr 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Saskia HaegensRanulfo Romo
Jun 18, 2009·Experimental Brain Research·Rainer Goebel, Nienke van Atteveldt
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Igor KaganRichard A Andersen
Sep 1, 2010·Cognitive Neuroscience·Naotsugu Tsuchiya, Jeroen J A van Boxtel
Dec 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Leila ReddyRufin VanRullen
Mar 4, 2015·NeuroImage·Natalia Zaretskaya, Andreas Bartels

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