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Divergence of hedgehog signal transduction mechanism between Drosophila and mammals

Developmental Cell

Feb 7, 2006

Markku VarjosaloJussi Taipale

Abstract

The Hedgehog (Hh) signaling pathway has conserved roles in development of species ranging from Drosophila to humans. Responses to Hh are mediated by the transcription factor Cubitus interruptus (Ci; GLIs 1-3 in mammals), and constitutive activation of Hh target gene expression has been ...read more

Mentioned in this Paper

Hedgehog Proteins
Biochemical Pathway
Conserved Sequence
SUFU
Exertion
Cosuppression
Drosophila melanogaster Proteins
Elbow
Transcription, Genetic
Mutagenesis, Site-Directed
119
1
Paper Details
References
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  • Citations122
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  • References37
  • Citations122
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Divergence of hedgehog signal transduction mechanism between Drosophila and mammals

Developmental Cell

Feb 7, 2006

Markku VarjosaloJussi Taipale

PMID: 16459297

DOI: 10.1016/j.devcel.2005.12.014

Abstract

The Hedgehog (Hh) signaling pathway has conserved roles in development of species ranging from Drosophila to humans. Responses to Hh are mediated by the transcription factor Cubitus interruptus (Ci; GLIs 1-3 in mammals), and constitutive activation of Hh target gene expression has been ...read more

Mentioned in this Paper

Hedgehog Proteins
Biochemical Pathway
Conserved Sequence
SUFU
Exertion
Cosuppression
Drosophila melanogaster Proteins
Elbow
Transcription, Genetic
Mutagenesis, Site-Directed
119
1

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Parasite evolution

Parasite evolution involves the heritable genetic changes that a parasite accumulates during its life time. Discover the latest research on parasite evolution here.

Signal Transduction & Control of Gene Expression

Expression of genes are thought to be involved in signaling pathways, which are important for cell growth, metabolism, apoptosis and more. It is thought that gene expression plays a part in the signaling pathways that implicates the biological effects of the cell. Here is the latest research on signal transduction and the control of gene expression.

Related Papers

Paper Details
References
  • References37
  • Citations122
1234
  • References37
  • Citations122
12345...
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