Divergence of quaternary structures among bacterial flagellar filaments

Science
Vitold E GalkinEdward H Egelman

Abstract

It has been widely assumed that the atomic structure of the flagellar filament from Salmonella typhimurium serves as a model for all bacterial flagellar filaments given the sequence conservation in the coiled-coil regions responsible for polymerization. On the basis of electron microscopic images, we show that the flagellar filaments from Campylobacter jejuni have seven protofilaments rather than the 11 in S. typhimurium. The vertebrate Toll-like receptor 5 (TLR5) recognizes a region of bacterial flagellin that is involved in subunit-subunit assembly in Salmonella and many other pathogenic bacteria, and this short region has diverged in Campylobacter and related bacteria, such as Helicobacter pylori, which are not recognized by TLR5. The driving force in the change of quaternary structure between Salmonella and Campylobacter may have been the evasion of TLR5.

References

Sep 5, 1976·Journal of Molecular Biology·R Kamiya, S Asakura
Dec 1, 1976·Journal of Molecular Biology·R Kamiya, S Asakura
May 8, 1975·Nature·C R Calladine
Jan 23, 1992·Nature·R M StoryT A Steitz
Aug 1, 1991·Journal of Bacteriology·P GuerryT J Trust
Jun 22, 2000·Journal of Molecular Biology·L A KelleyM J Sternberg
Oct 19, 2004·Trends in Microbiology·Hugo Cruz RamosJean-Claude Sirard
May 28, 2005·Current Opinion in Structural Biology·William R Pearson, Michael L Sierk
Jun 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Erica Andersen-NissenAlan Aderem
Dec 22, 2005·Infection and Immunity·Scarlett GoonPatricia Guerry
Mar 17, 2006·Trends in Microbiology·Scott A BeatsonMark J Pallen
Sep 18, 2007·Nature Structural & Molecular Biology·Albina OrlovaEdward H Egelman
Oct 9, 2007·Trends in Microbiology·Patricia Guerry

❮ Previous
Next ❯

Citations

Aug 29, 2013·International Journal of Hematology·Yoshinobu Maeda
Mar 17, 2010·Nature Structural & Molecular Biology·Saori Maki-YonekuraKeiichi Namba
May 18, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·Laurent Terradot, Marie-Francoise Noirot-Gros
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nicolas BiaisMichael P Sheetz
Feb 19, 2010·The Journal of Biological Chemistry·Marcel R de ZoeteJos P M van Putten
Dec 6, 2011·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Yasuji KidoFadel A Samatey
Jun 5, 2012·Applied and Environmental Microbiology·Wen-Yan ZhangLong-Fei Wu
Dec 20, 2012·Infection and Immunity·Alexander C MauePatricia Guerry
Sep 15, 2009·Journal of Bacteriology·Cheryl P EwingPatricia Guerry
Aug 12, 2008·Journal of Bacteriology·Joo-Sung KimStuart A Thompson
Oct 22, 2008·Journal of Bacteriology·Francois P DouillardPaul W O'Toole
Mar 5, 2011·Microbiology and Molecular Biology Reviews : MMBR·Jeremy J GilbreathDavid R Hendrixson
Oct 17, 2008·Canadian Journal of Microbiology·Michael G PyatibratovOleg V Fedorov
Feb 22, 2014·PloS One·Krystle L MohawkPatricia Guerry
Apr 2, 2009·Expert Opinion on Therapeutic Targets·Athanasios KatsargyrisStamatios Theocharis
Apr 29, 2009·Expert Review of Vaccines·Elzbieta Katarzyna Jagusztyn-KrynickaAgnieszka Wyszyńska
Jan 27, 2015·Structure·E H EgelmanV P Conticello
Nov 23, 2015·Current Opinion in Microbiology·Morgan Beeby
Dec 17, 2008·Trends in Microbiology·Lori A S SnyderMark J Pallen
Aug 19, 2008·Trends in Microbiology·Patricia Guerry, Christine M Szymanski
May 6, 2008·Journal of Molecular Biology·Mikako FujiiShin-Ichi Aizawa
Oct 20, 2012·Environmental Microbiology·Anna-Lena HencheSonja-Verena Albers
Jun 16, 2011·The EMBO Journal·Songye ChenGrant J Jensen
Nov 2, 2011·Environmental Microbiology·Alexandre Jousset
Jul 30, 2014·MicrobiologyOpen·Axel MüllerWilliam M Clemons
Aug 19, 2015·Frontiers in Microbiology·Mark ReuterArnoud H M van Vliet
Apr 26, 2015·Seminars in Immunology·Gernot Sellge, Thomas A Kufer
Nov 17, 2009·Structure·Edward H Egelman
Jul 8, 2008·Journal of Molecular Biology·Ying A WangEdward H Egelman
Jan 16, 2015·PLoS Pathogens·Yannick RossezNicola J Holden
Sep 1, 2016·Proceedings of the National Academy of Sciences of the United States of America·Tatjana BraunEdward H Egelman
Oct 21, 2016·Scientific Reports·Young-Ho YoonFadel A Samatey
Oct 21, 2016·ELife·Sandra PostelEric J Sundberg
Nov 5, 2016·Nature Communications·Hideyuki MatsunamiFadel A Samatey
Jan 21, 2017·Scientific Reports·Wan Seok SongSung-Il Yoon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Campylobacteriosis (ASM)

Campylobacteriosis is caused by the bacteria Campylobacter jejuni and is a common cause of gastroenteritis in humans. Discover the latest research on Campylobacteriosis here.