Divergent action of fluoxetine in zebrafish according to responsivity to novelty

Scientific Reports
Débora FiorLeonardo José Gil Barcellos

Abstract

Here we show that the novel object recognition test can discriminate between high (HRN, neophobic) and low (LRN, neophilic) novelty responders in zebrafish populations. Especially when we observe the latency to the first entry in the novel object zone, zebrafish did not maintain these behavioral phenotypes in sequential tests and only the HRN group returned to their initial responsive behavior when exposed to fluoxetine. Our results have important implications for behavioral data analysis since such behavioral differences can potentially increase individual response variability and interfere with the outcomes obtained from various behavioral tasks. Our data reinforce the validity of personality determination in zebrafish since we show clear differences in behavior in response to fluoxetine.

References

Sep 14, 2000·Genome Research·W B BarbazukS L Johnson
Sep 28, 2002·Proceedings. Biological Sciences·David H Foster, Stuart J Gilson
Jun 23, 2005·Behavioural Brain Research·Vanessa KazlauckasDiogo R Lara
Apr 18, 2007·Biological Reviews of the Cambridge Philosophical Society·Denis RéaleNiels J Dingemanse
Jan 17, 2009·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Derek Alsop, Mathilakath M Vijayan
Sep 15, 2009·Trends in Ecology & Evolution·Niels J DingemanseJonathan Wright
Aug 4, 2010·BMC Neuroscience·William Norton, Laure Bally-Cuif
Nov 3, 2010·Biochimica Et Biophysica Acta·Keith B Tierney
Dec 17, 2010·Zebrafish·Caio Maximino, Anderson Manoel Herculano
Dec 29, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ângelo L PiatoCarla D Bonan
Nov 1, 1994·Trends in Ecology & Evolution·D Sloan WilsonT Dearstyne
Jan 18, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Caio MaximinoAnderson Manoel Herculano
May 28, 2011·Reviews in the Neurosciences·Adam StewartAllan V Kalueff
Aug 23, 2011·PloS One·S Josefin DahlbomSvante Winberg
Sep 7, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gabriele GhisleniCarla D Bonan
Dec 31, 2011·Neuroscience and Biobehavioral Reviews·Dominik KiserJudith R Homberg
Jan 29, 2013·Behavior Genetics·Tolulope O AriyomoPenelope J Watt
Apr 18, 2013·Zebrafish·Allan V KalueffUNKNOWN Zebrafish Neuroscience Research Consortium
Oct 3, 2013·Behavioural Brain Research·Steven Tran, Robert Gerlai
Nov 23, 2013·Neuroscience Letters·Glaucia Dal SantoAngelo L Piato
Apr 1, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Daniela BraidaMariaelvina Sala
Apr 8, 2014·Behavioural Processes·Tyrone Lucon-Xiccato, Marco Dadda
Feb 13, 2015·Zebrafish·Jessica OliveiraAna Luchiari
May 23, 2015·Journal of Applied Toxicology : JAT·Zachary A BaultJennifer L Freeman
Sep 1, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Steven TranRobert Gerlai
Sep 17, 2015·Behavioural Brain Research·Zacnicte MayTrevor James Hamilton
Sep 26, 2015·Behavioural Brain Research·Ana Cristina V V GiacominiLeonardo J G Barcellos
Oct 16, 2015·Ecotoxicology·Teresa L DzieweczynskiLindsey E Lavin
Mar 18, 2016·The Journal of Experimental Biology·Teresa L DzieweczynskiJessica L Kane
Jun 23, 2016·Zebrafish·Bernardus W M M PeetersAnne R J Veenvliet
Jun 29, 2016·Scientific Reports·Ana Cristina V V GiacominiLeonardo J G Barcellos
Oct 26, 2016·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Murilo S AbreuLeonardo J G Barcellos
Nov 2, 2016·Molecules and Cells·Jong-Su ParkCheol-Hee Kim
Jan 18, 2018·Scientific Reports·Karina KirstenLeonardo José Gil Barcellos

❮ Previous
Next ❯

Citations

Nov 14, 2019·Journal of Neuroscience Research·Murilo S de AbreuMarta C Soares
Nov 6, 2020·Archives of Environmental Contamination and Toxicology·Martin Kellner, K Håkan Olsén
May 15, 2020·Physiology & Behavior·Suelen Mendonça SoaresLeonardo José Gil Barcellos

❮ Previous
Next ❯

Software Mentioned

maze
ANY

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Scientific Reports
Karina KirstenLeonardo José Gil Barcellos
The Journal of Nervous and Mental Disease
T J McLaughlin, C N Lewis
International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology
K A Lawler
© 2022 Meta ULC. All rights reserved