PMID: 9194692Jan 1, 1997Paper

Divergent actions of chronic insulin treatment in vivo versus acute treatment ex vivo on diabetic-induced endothelial dysfunction

Life Sciences
G M Pieper

Abstract

Streptozotocin-induced diabetes is associated with hyperglycemia and hypoinsulinemia. The role of insulin in diabetes-induced endothelial dysfunction is unknown. In the present study, we evaluated the effect of chronic insulin treatment in vivo versus acute insulin administration ex vivo on endothelium-dependent relaxation in aortic rings of the streptozotocin-induced diabetic rat. Relaxation to acetylcholine (but not A23187) was impaired in diabetic compared to control rings. This defect was prevented by chronic insulin treatment but was not reversed by acute insulin administration ex vivo. Thus, endothelial dysfunction in the streptozotocin-induced diabetic rat is specific for the chronic diabetic state and not to vascular toxicity of streptozotocin. Nevertheless, it is apparent that insulin at a physiological concentration does not cause an acute direct effect on facilitating endothelium-dependent relaxation in diabetic blood vessels.

References

Apr 1, 1989·Journal of Cardiovascular Pharmacology·Y TakiguchiM Nakashima
Jan 1, 1989·General Pharmacology·V M AltanA T Ozçelikay
Mar 1, 1995·Journal of Cardiovascular Pharmacology·G M Pieper, B A Peltier
Dec 1, 1994·The Journal of Clinical Investigation·U ScherrerP Nicod
May 1, 1993·Circulation·V Gurewich

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Citations

Apr 11, 2012·International Journal of Vascular Medicine·Steven Daniel FunkA Wayne Orr
Sep 25, 2012·International Journal of Dermatology·Michael Wolz
Jul 22, 2014·Advances in Physiology Education·Charles M Tipton
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Tsuneo Kobayashi, Katsuo Kamata
May 8, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Tsuneo KobayashiKatsuo Kamata

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