Divergent actions of the pyrethroid insecticides S-bioallethrin, tefluthrin, and deltamethrin on rat Na(v)1.6 sodium channels.

Toxicology and Applied Pharmacology
Jianguo Tan, David M Soderlund

Abstract

We expressed rat Na(v)1.6 sodium channels in combination with the rat beta(1) and beta(2) auxiliary subunits in Xenopus laevis oocytes and evaluated the effects of the pyrethroid insecticides S-bioallethrin, deltamethrin, and tefluthrin on expressed sodium currents using the two-electrode voltage clamp technique. S-Bioallethrin, a type I structure, produced transient modification evident in the induction of rapidly decaying sodium tail currents, weak resting modification (5.7% modification at 100 microM), and no further enhancement of modification upon repetitive activation by high-frequency trains of depolarizing pulses. By contrast deltamethrin, a type II structure, produced sodium tail currents that were ~9-fold more persistent than those caused by S-bioallethrin, barely detectable resting modification (2.5% modification at 100 microM), and 3.7-fold enhancement of modification upon repetitive activation. Tefluthrin, a type I structure with high mammalian toxicity, exhibited properties intermediate between S-bioallethrin and deltamethrin: intermediate tail current decay kinetics, much greater resting modification (14.1% at 100 microM), and 2.8-fold enhancement of resting modification upon repetitive activation. Comparison of ...Continue Reading

Citations

Apr 8, 2014·Insect Biochemistry and Molecular Biology·Ke DongBoris S Zhorov
Apr 16, 2014·Toxicology and Applied Pharmacology·Thomas J Nutter, Brian Y Cooper
Jun 29, 2011·Archives of Toxicology·David M Soderlund
Nov 20, 2012·Invertebrate Neuroscience : in·Dmitry DiykovJeffrey R Bloomquist
Mar 22, 2014·Drug and Chemical Toxicology·DeQing CaoLi An
May 12, 2012·Pesticide Biochemistry and Physiology·Jianguo TanDavid M Soderlund
Oct 4, 2011·Pesticide Biochemistry and Physiology·Jianguo Tan, David M Soderlund
Oct 9, 2013·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Jaakko Haverinen, Matti Vornanen
Mar 29, 2011·Biochemical and Biophysical Research Communications·Jianguo Tan, David M Soderlund
Dec 8, 2010·Journal of Agricultural and Food Chemistry·Hideo Kaneko
Feb 10, 2017·Environmental Toxicology·Golla Madhubabu, Suresh Yenugu
Nov 2, 2014·Journal of Biochemical and Molecular Toxicology·Jason P Magby, Jason R Richardson
Sep 24, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Muhammad M HossainJason R Richardson
Aug 15, 2021·Toxicology and Applied Pharmacology·Stefanie Nicole Bothe, Angelika Lampert

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