Divergent acute and chronic modulation of glutamatergic postsynaptic density genes expression by the antipsychotics haloperidol and sertindole.

Psychopharmacology
F IasevoliAndrea de Bartolomeis

Abstract

A pivotal role for glutamate in the pathophysiology and treatment of schizophrenia has been suggested. Few reports have investigated the impact of antipsychotics on postsynaptic density (PSD) molecules involved in glutamatergic transmission and synaptic remodeling. Homer is a key PSD molecule putatively implicated in schizophrenia. We studied the effect, in acute and chronic paradigms, of a first and a second generation antipsychotic (haloperidol and sertindole, respectively) on the expression of Homer1a and Homer-interacting PSD molecules. In the acute paradigm, Homer1a expression was induced by haloperidol but not sertindole in the striatum, consistent with the less propensity of sertindole to affect nigrostriatal neurotransmission. The profile of expression of two other inducible genes, Ania3 and Arc, was highly similar to Homer1a. In the cortex, haloperidol reduced Homer1a and induced Ania3. In the chronic paradigm, striatal expression of Homer1a and Ania3 resembled that observed in the acute paradigm. In the cortex, haloperidol induced Homer1a, while sertindole did not. Homer1b expression was increased by haloperidol in the striatum and cortex whereas sertindole selectively induced Homer1b in the cortex. The expression of ...Continue Reading

References

Jan 16, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J Arnt, T Skarsfeldt
Oct 21, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·X M GaoC A Tamminga
Feb 9, 2002·Brain Research. Molecular Brain Research·Andrea de BartolomeisPaolo Barone
Jul 3, 2002·Molecular and Cellular Neurosciences·Fabrice AngoLaurent Fagni
Dec 5, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniela PoleseAndrea de Bartolomeis
Feb 1, 2003·Pharmacology & Therapeutics·Christine Konradi, Stephan Heckers
Jun 20, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·N NortonM J Owen
Jul 5, 2003·Brain Research. Brain Research Protocols·Alberto Ambesi-ImpiombatoAndrea de Bartolomeis
Mar 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Limin MaoJohn Q Wang
May 6, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carlo SalaLaurent Fagni
Jul 14, 2005·Genes, Brain, and Behavior·K K SzumlinskiP W Kalivas
Dec 2, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sridhar NatesanShitij Kapur
Dec 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kevin D LominacKaren K Szumlinski
Jan 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Anke Tappe, Rohini Kuner
May 18, 2006·Current Opinion in Neurobiology·Karen K SzumlinskiPaul F Worley
Oct 5, 2006·The Journal of Clinical Psychiatry·Keming GaoJoseph R Calabrese
Jan 20, 2007·Molecular Pharmacology·Guo-Chi ZhangJohn Q Wang
Jan 25, 2007·Annual Review of Biochemistry·Morgan Sheng, Casper C Hoogenraad
Feb 27, 2007·Molecular and Cellular Neurosciences·Shigeo Okabe
Mar 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Paul J Kammermeier, Paul F Worley
Dec 7, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Fabrizio GardoniFabio Fumagalli
Dec 21, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joshua S RodeferJørn Arnt

❮ Previous
Next ❯

Citations

Aug 2, 2014·Expert Opinion on Pharmacotherapy·Maria Rosaria Anna MuscatelloRocco Antonio Zoccali
Jul 16, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Felice IasevoliAndrea de Bartolomeis
Jan 30, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Andrea de BartolomeisFelice Iasevoli
Jul 10, 2013·European Journal of Pharmacology·Andrea de BartolomeisCarmine Tomasetti
May 15, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Andrea de BartolomeisFelice Iasevoli
Dec 15, 2017·Neural Plasticity·Nicholas E CliftonJeremy Hall
May 23, 2018·Medicinal Research Reviews·Xu-Feng Huang, Xueqin Song
Jul 3, 2018·Biological & Pharmaceutical Bulletin·Shinsuke NakamuraHideaki Hara
Apr 2, 2015·Journal of Clinical Psychopharmacology·Rocco A ZoccaliMaria Rosaria Anna Muscatello
Aug 18, 2017·Journal of Neural Transmission·Stefan L LeberSerge Weis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here