Divergent cortical generators of MEG and EEG during human sleep spindles suggested by distributed source modeling.

PloS One
Nima DehghaniEric Halgren

Abstract

Sleep spindles are approximately 1-second bursts of 10-15 Hz activity, occurring during normal stage 2 sleep. In animals, sleep spindles can be synchronous across multiple cortical and thalamic locations, suggesting a distributed stable phase-locked generating system. The high synchrony of spindles across scalp EEG sites suggests that this may also be true in humans. However, prior MEG studies suggest multiple and varying generators. We recorded 306 channels of MEG simultaneously with 60 channels of EEG during naturally occurring spindles of stage 2 sleep in 7 healthy subjects. High-resolution structural MRI was obtained in each subject, to define the shells for a boundary element forward solution and to reconstruct the cortex providing the solution space for a noise-normalized minimum norm source estimation procedure. Integrated across the entire duration of all spindles, sources estimated from EEG and MEG are similar, diffuse and widespread, including all lobes from both hemispheres. However, the locations, phase and amplitude of sources simultaneously estimated from MEG versus EEG are highly distinct during the same spindles. Specifically, the sources estimated from EEG are highly synchronous across the cortex, whereas those...Continue Reading

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Citations

Nov 12, 2013·Trends in Neurosciences·Simone AstoriAnita Lüthi
Jun 12, 2012·Oral Oncology·Chih-Yen ChienChang-Han Chen
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Methods Mentioned

BETA
Synthetic

Software Mentioned

LORETA
Polhemus FastTrack
Freesurfer

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