Divergent effects of caloric restriction on gene expression in normal and long-lived mice

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Michal M MasternakAndrzej Bartke

Abstract

Long-lived Ames dwarf mice share many phenotypic characteristics with animals subjected to caloric restriction (CR) but they are not CR mimetics. CR prolongs longevity in both normal and Ames dwarf mice. Using real-time polymerase chain reaction and western blot, we have examined the expression of genes related to insulin signaling in the liver of normal and dwarf mice subjected to 30% CR. The results revealed divergent responses of dwarf and normal animals to CR raising an interesting possibility that CR may affect longevity of normal and dwarf mice by different mechanisms. Moreover, effects of dwarfism on the expression of the examined genes differed from the effects of CR, thus adding to the evidence that these long-lived mutants are not CR mimetics.

References

Jan 1, 1992·Pediatric Research·S U Devaskar, M M Mueckler
Mar 1, 1990·Diabetes Care·B ThorensH F Lodish
Sep 14, 1995·Nature·X J SunM F White
Nov 7, 1996·Nature·H M Brown-BorgA Bartke
Jan 16, 1999·The Journal of Biological Chemistry·M P Czech, S Corvera
May 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·K FlurkeyD E Harrison
Jun 11, 2002·Annual Review of Nutrition·Frédéric Picard, Johan Auwerx
Jun 12, 2002·The American Journal of Pathology·Isao ShimokawaHaruyoshi Yamaza
Oct 31, 2002·Molecular Endocrinology·Richard A MillerAndrzej Bartke
Dec 17, 2002·Nature·Martin HolzenbergerYves Le Bouc
Jan 15, 2003·Annual Review of Medicine·Stephen D HurstingJ Carl Barrett
Jan 31, 2003·American Journal of Physiology. Endocrinology and Metabolism·Philip D G MilesJerrold M Olefsky
Mar 1, 2003·Science·Marc TatarAdam Antebi
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·Mark GurnellStephen O'Rahilly

❮ Previous
Next ❯

Citations

Jun 7, 2005·Experimental Gerontology·Michal M MasternakAndrzej Bartke
Mar 5, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Audreen LouisMichal M Masternak
Aug 20, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jacob A PaniciMichal M Masternak
Oct 31, 2013·Reviews in Endocrine & Metabolic Disorders·Bonggi Lee, Jianhua Shao
Aug 29, 2014·Age·Denise S WiesenbornMichal M Masternak
Feb 16, 2016·Experimental Gerontology·José Alberto López-DomínguezJon J Ramsey
Aug 20, 2008·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Darlene E BerrymanJohn J Kopchick
May 17, 2005·Mechanisms of Ageing and Development·David A Sinclair
Oct 2, 2014·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Lorna MulveyColin Selman
Aug 26, 2014·Experimental Gerontology·Adam GesingMichal M Masternak
Dec 30, 2014·Journal of Ovarian Research·Augusto SchneiderMichal M Masternak
May 16, 2015·Blood Cells, Molecules & Diseases·Maegan L CapitanoHal E Broxmeyer
Sep 25, 2016·Molecular and Cellular Endocrinology·Augusto SchneiderMichal M Masternak
Oct 1, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Adam GesingMichal M Masternak
Jan 4, 2017·PloS One·Augusto SchneiderMichal M Masternak
Mar 5, 2008·PPAR Research·Adnan Erol
Feb 14, 2018·The Journal of Endocrinology·Marleen B DommerholtJames D Johnson
Nov 1, 2006·Expert Review of Endocrinology & Metabolism·Michal M Masternak, Andrzej Bartke
Sep 6, 2019·GeroScience·Gabriela ColonMichal M Masternak
Jan 21, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·J Christopher Corton, Holly M Brown-Borg
Feb 4, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jie ChenRunsheng Ruan
Jan 26, 2016·Aging·María Eugenia MatzkinMónica Beatriz Frungieri
Dec 20, 2019·Scientific Reports·Augusto SchneiderKyle H Rohde
Oct 31, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Denise S WiesenbornMichal M Masternak
Mar 29, 2007·PPAR Research·Michal M Masternak, Andrzej Bartke
Jun 18, 2021·Mechanisms of Ageing and Development·Mónica B FrungieriMaría E Matzkin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.